Results 231 to 240 of about 31,176 (296)

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Analytical and Clinical Validation of a Serum microRNA RT-qPCR Assay for Detection of Acute Cellular Rejection in Liver Transplant Recipients. [PDF]

Diagnostics (Basel)
Wang Y, Huff R, Parker H, Han C, Lee BI, Huang S, Burke M, Loza BL, Keating BJ, Olthoff K, Shaked A.   +10 more
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Comparative evaluation of Hepassocin, DCP, and AFP-L3 for non-invasive assessment of liver fibrosis in Hepatitis B infection. [PDF]

BMC Infect Dis
Nair DM, Vajravelu LK, Paneerselvam V, Lathakumari RH, Vimala PB, Thulukanam J.   +5 more
europepmc   +1 more source

Using Preoperative Therapeutic Plasma Exchange in Lupus Anticoagulant Hypoprothrombinemia Syndrome to Achieve Hemostatic Factor II Activity: A Case Report. [PDF]

J Clin Apher
Panwar P, Yates SG, Yarborough R, Shen YM.   +3 more
europepmc   +1 more source

Positive selection on brain cis-regulatory elements in the human lineage drives changes in gene expression and susceptibility to neuropsychiatric disorders. [PDF]

HGG Adv
Touissi Y, Vallender EJ.
europepmc   +1 more source

Increasing the Compositional Heterogeneity of Single-Chain Amphiphile Membranes Supported by Coacervate Cores Alters Stability and Properties of the Hybrid Protocells. [PDF]

Langmuir
Joshi MP, Lee J, Chan M, Keating CD.
europepmc   +1 more source

Validating superior maize hybrids in all India coordinated trials using REMATTOOL-R: a decision support approach. [PDF]

Front Plant Sci
Neelam S, Bhoga J, Bellamkonda J, Dharavath B, Choudhary M, Kumar P, Phagna RK, Singh SB, Appavoo D, Jat HS.   +9 more
europepmc   +1 more source

Health Professionals' Approaches to Support Patient Diversity in the Assessment of Vaginismus: A Critical Feminist Qualitative Study for Inclusive Care. [PDF]

Healthcare (Basel)
Pithavadian R, Ramanathan V, Micheal S, Dune T.   +3 more
europepmc   +1 more source