Results 281 to 290 of about 297,952 (346)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post   +4 more
wiley   +1 more source

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium

open access: yesBritish Journal of Haematology, EarlyView.
The overall survival of patients receiving an allogeneic haematopoietic stem cell transplant (HSCT) for GATA2 deficiency was significantly better if they were transplanted recently, with a bone marrow or cord blood graft and if the transplant was performed before the onset of excess blast. Excess blast before HSCT was the only factor associated with an
Flore Sicre de Fontbrune   +20 more
wiley   +1 more source

Single‐Cell Transcriptomics Identifies Novel Prognostic Signatures in HNSCC Immunotherapy Response

open access: yesCancer Science, EarlyView.
This study demonstrates the value of combining single‐cell and bulk RNA sequencing approaches to understand HNSCC tumor biology and treatment response. The developed prognostic model and identified immune signatures provide a foundation for improving patient stratification and treatment selection.
Kankui Wu   +8 more
wiley   +1 more source

Head and Neck Cancer Immunotherapy: Overcoming Limitations and Enhancing Efficacy

open access: yesCancer Science, EarlyView.
ICI‐included therapies are standard for R/M HNSCC patients. In particular, neoadjuvant ICI therapy shows promising clinical results even in nontreated resectable HNSCC patients. In addition, cancer vaccine, immune cell‐based therapy, immunomodulation therapy, and TME targeting therapy may combine with ICI.
Hirofumi Shibata   +8 more
wiley   +1 more source

Effect of orally administered L. crispatus M247 in favoring HR-HPV clearance and CST shift: results from a randomized, multi-center, placebo-controlled trial. [PDF]

open access: yesSci Rep
Di Pierro F   +17 more
europepmc   +1 more source

Neutralization of Human Papillomavirus (HPV) Pseudovirions: A Novel and Efficient Approach to Detect and Characterize HPV Neutralizing Antibodies

open access: bronze, 2000
Mark D. Yeager   +11 more
openalex   +1 more source

Microbial and Metabolic Disorders in Cervical Cancer: Structural Insights, Biomarkers, Mechanisms, and Therapeutic Strategies

open access: yesCancer Science, EarlyView.
We unravel synergistic mechanisms by which microbial‐host metabolic networks regulate the tumor immune microenvironment and therapy resistance, bridging gaps between microbiota research and cancer metabolism. Identified biomarkers (e.g., Lactobacillus, C8‐ceramide‐1‐phosphate) and therapeutic approaches (e.g., FMT combined with immune checkpoint ...
Hong Tao   +6 more
wiley   +1 more source

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