Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain [PDF]
Scientific Reports, 2022 Oncogenic protein E6 from Human Papilloma Virus 16 (HPV-16) mediates the degradation of Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI-1), throughout the interaction of its protein binding motif (PBM) with the Discs-large ...
Lilian Esmeralda Araujo-Arcos +5 more
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Expressions of HPV 16-E6 in esophageal carcinoma and it's clinical significance
Asian Journal of Medical Sciences, 2015 Aim: To explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma. Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10
Xing Zhao
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Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes [PDF]
Virology Journal, 2012 Background The human papillomavirus (HPV) life cycle is closely linked to keratinocyte differentiation. Oncogenic HPV infection has been shown to hamper the normal differentiation of keratinocytes; however, the underlying mechanisms responsible for this ...
Gyöngyösi Eszter +5 more
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C-71980262, A novel small molecule against human papilloma virus-16 E6 (HPV-16 E6) with anticancer potency against cervical cancer: A computational guided in vitro approach [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Human papillomavirus-16 E6 (HPV-16 E6) forms a heterodimer complex to up-regulate the degradation of tumor suppressor protein p53 to promote cervical cancer.
Ashish Kumar
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Tumour Virus Research, 2023 Human papillomavirus (HPV) E6 and E7 oncogene expression is essential for cervical carcinogenesis. Evidence exists that E6/E7 variants may have different transforming activities while the risk of HPV-16 variants (A/D) differs by race/ethnicity.
Gladys Kaba +9 more
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The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
Virology Journal, 2022 Background The Alphapapillomavirus 9 (α-9 HPV) is a member of the Alphapapillomavirus genus and Papillomaviridae family. These viruses are almost all carcinogenic HPV, which is closely related to 75% of invasive cervical cancer worldwide, and has a high ...
Jiaoyu He +10 more
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Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China
Virology Journal, 2023 Background Persistent high-risk human papillomavirus (HR-HPV) infection is an important factor in the development of cervical cancer, and human papillomavirus type 16 (HPV-16) is the most common HR-HPV type worldwide. The oncogenic potential of HPV-16 is
Ting Li +4 more
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Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. [PDF]
PLoS Pathogens, 2011 The E6 oncoprotein from high-risk genus alpha human papillomaviruses (α-HPVs), such as HPV 16, has been well characterized with respect to the host-cell proteins it interacts with and corresponding signaling pathways that are disrupted due to these ...
Heather L Howie +6 more
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HPV transcript expression affects cervical cancer response to chemoradiation
JCI Insight, 2021 Persistent HPV infection is causative for the majority of cervical cancer cases; however, current guidelines do not require HPV testing for newly diagnosed cervical cancer.
Fiona J. Ruiz +11 more
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Eight nucleotide substitutions inhibit splicing to HPV-16 3'-splice site SA3358 and reduce the efficiency by which HPV-16 increases the life span of primary human keratinocytes. [PDF]
PLoS ONE, 2013 The most commonly used 3'-splice site on the human papillomavirus type 16 (HPV-16) genome named SA3358 is used to produce HPV-16 early mRNAs encoding E4, E5, E6 and E7, and late mRNAs encoding L1 and L2. We have previously shown that SA3358 is suboptimal
Xiaoze Li +6 more
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