Results 161 to 170 of about 32,749 (181)

Differential Distribution of Sequence Variations in HPV-16 E6

Gynecologic Oncology, 2000
The E6 regions of the oncogenic human papillomaviruses (HPVs) are important in carcinogenesis and immune recognition. We examined the E6 DNA sequence from HPV-16-associated cervical cancers to determine the frequency and degree of variation from the consensus sequence in selected populations.Samples positive for HPV-16 were analyzed using polymerase ...
B S, Gostout, G M, Zanetta, S, Maleemonkol, M R, Kamat, R M, McGovern, D H, Persing   +5 more
openaire   +2 more sources

POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA

International Journal of Oncology, 1995
Polymorphism of the human papillomavirus type 16 (HPV-16) genome has been reported to occur within the noncoding regulatory long control region (LCR) and in the E7 and L1 genes. The current study focuses on the HPV-16 E6 oncogene which interacts with the antioncogenic regulator p53.
R, Burger, L, Alvarezsalas, S, Wilczynski, B, Monk, J, Dipaolo   +4 more
openaire   +2 more sources

HPV 16 E6 sequence variations in Indian patients with cervical neoplasia

Cancer Letters, 2005
In a cross-sectional study performed between June 2001 and November 2003, the HPV 16 E6 gene of 50 women with cervical neoplasia and 20 cytologically normal women ('controls') was sequenced following amplification by PCR. The 350T to G variant was seen in 35 (70%) of 50 patients' isolates while it was seen in only 3 (15%) of the 20 isolates from the ...
Narayanan, Sathish, Priya, Abraham, Abraham, Peedicayil, Gopalan, Sridharan, George, Chandy   +4 more
openaire   +2 more sources

Conservation of HPV‐16 E6/E7 ORF sequences in a cervical carcinoma

Journal of Medical Virology, 1992
AbstractA cervical carcinoma that contained human papillomavirus (HPV)‐l6 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV‐16 DNA. The E6 and E7 open reading frames (ORFs) were com‐ pletely conserved relative to other published HPV‐I6 sequences.
R W, Cone, A C, Minson, M R, Smith, J K, McDougall   +3 more
openaire   +2 more sources

Human keratin 14 driven HPV 16 E6/E7 transgenic mice exhibit hyperkeratinosis

Life Sciences, 2004
Human papillomavirus type 16 (HPV16) has been known as a major causative factor for the development of uterine cervical carcinomas. To investigate the in vivo activity of HPV16 expressed in squamous epithelia, transgenic mice harboring HPV16 E6/E7 with human keratin 14 (hK14) promoter were generated.
Sung-Hyun, Kim, Kil-Soo, Kim, Eun-Ju, Lee, Myoung-Ok, Kim, Jun-Hong, Park, Kyoung-In, Cho, Kazuhiko, Imakawa, Byung-Hwa, Hyun, Kyu-Tae, Chang, Hoon Taek, Lee, Zae-Young, Ryoo   +10 more
openaire   +2 more sources

Cleavage of HPV-16 E6/E7 mRNA Mediated by Modified 10–23 Deoxyribozymes

Oligonucleotides, 2009
Deoxyribozymes (DXZs) are small oligodeoxynucleotides capable of mediating phosphodiester bond cleavage of a target RNA in a sequence-specific manner. These molecules are a new generation of artificial catalytic nucleic acids currently used to silence many disease-related genes.
Pablo, Reyes-Gutiérrez, Luis M, Alvarez-Salas   +1 more
openaire   +2 more sources

The relationship between cytokines and HPV-16, HPV-16 E6, E7, and high-risk HPV viral load in the uterine cervix

Gynecologic Oncology, 2007
To investigate intralesional cytokine levels in precancerous lesions of the uterine cervix and their relationship with human papillomavirus (HPV) type 16, HPV type 16 E6/E7, and high-risk HPV viral load.We performed a prospective study of 67 patients between May 2005 and December 2005.
Seung-Hun, Song, Jae-Kwan, Lee, Oye-Sun, Seok, Ho-Suk, Saw   +3 more
openaire   +2 more sources

HPV-16 E6 oncoprotein induces mutations via p53-dependent and -independent pathways.

Oncology Reports, 2000
The E6 oncoprotein of human papillomaviruses (HPV) promotes oncogenesis by inactivating tumor suppressor protein p53 i. e. it binds to and enhances the degradation of p53. To study whether inactivation of p53 is solely responsible for E6-induced oncogenesis, we constructed several plasmid vectors expressing wild-type (wt) or mutant (mt) E6 proteins ...
H J, Kim, W, Guo, N H, Park
openaire   +2 more sources

Oncogenic Potential of Naturally Occurring HPV- 16 E6 Variants

2019
To date, approximately 200 different human papillomavirus types were shown to infect human epithelial cells. Fifteen of these have been classified as oncogenic or high-risk HPV types because of their etiological role in the development of cervical cancer, anogenital cancers, and some head-and-neck carcinomas.
Đukić, Anamaria, Thatte, Jayashree Vijay, Thomas, Miranda, Massimi, Paola, Skelin, Josipa, Lulić, Lucija, Banks, Lawrence, Tomaić, Vjekoslav   +7 more
openaire   +2 more sources

Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames

The Prostate, 1999
The exact pathogenesis for prostate cancer is not known. Progress made in prostate cancer research has been slow, largely due to the lack of suitable in vitro models. Here, we report our work on the immortalization of a human prostate epithelial cell line and show that it can be used as a model to study prostate tumorigenesis.Replication-defective ...
Zheng, Z, Chan, LC, Zhang, D, Ling, MT, Choo, CK, Wong, YC, Chan, KW, Tsao, SW   +7 more
openaire   +3 more sources