Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis [PDF]
Genomics & Informatics, 2014 Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs.
Satish Kumar +5 more
doaj +3 more sources
Molecular Variants of HPV Type 16 E6 Among Honduran Women [PDF]
International Journal of Gynecological Cancer, 2010 In this study, we investigated the prevalence of human papillomavirus 16 (HPV-16) variants in Honduran women with normal cytology and with dysplasia and cervical cancer.Samples identified as positive for HPV-16 by SPF10-LiPA were tested for intratypic subtypes and variants by analysis of the E6/E7 region using a novel reverse hybridization assay (line ...
Tabora, N. +4 more
openaire +2 more sources
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors [PDF]
Cancer Gene Therapy, 2012 Human papillomaviruses (HPVs) are the causative factor for >90% of cervical cancers and 25% of head and neck cancers. The incidence of HPV positive (+) head and neck squamous cell carcinomas has greatly increased in the last 30 years. E6 and E7 are the two key viral oncoproteins that induce and propagate cellular transformation.
Wieking, Bryant G. +11 more
openaire +2 more sources
HPV-18 transformed cells fail to arrest in G1 in response to quercetin treatment [PDF]
, 2005 Previous work with primary human keratinocytes demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 with concomitant elevation of the cyclin-dependent kinase inhibitor (cdki ...
Alonso-Amelot +37 more
core +1 more source
Metabolic Reprogramming in Cancer: Role of HPV 16 Variants
Pathogens, 2021 Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called “aerobic glycolysis” or “Warburg ...
Adán Arizmendi-Izazaga +11 more
doaj +1 more source
Clinical characteristics of women diagnosed with carcinoma who tested positive for cervical and anal high-risk human papillomavirus DNA and E6 RNA [PDF]
, 2015 High-risk human papillomavirus (hrHPV) is an essential cause of cervical carcinoma and is also strongly related to anal cancer development. The hrHPV E6 oncoprotein plays a major role in carcinogenesis. We aimed to evaluate the frequency of hrHPV DNA and
Cinti, Claudia +9 more
core +1 more source
Virology Journal, 2020 Background Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their ...
Satoshi Baba +17 more
doaj +1 more source
Tobacco smoke activates human papillomavirus 16 p97 promoter and cooperates with high-risk E6/E7 for oxidative DNA damage in lung cells. [PDF]
PLoS ONE, 2015 We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins and cigarette smoke condensate (CSC) in lung cells suggesting cooperation during carcinogenesis.
Nelson Peña +9 more
doaj +1 more source
Human papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53. [PDF]
, 2016 Human β-defensin-3 (hBD3) is an epithelial cell-derived innate immune regulatory molecule overexpressed in oral dysplastic lesions and fosters a tumor-promoting microenvironment.
Androphy, Elliot J. +11 more
core +2 more sources
Gene Expression Profiles are Altered in Human Papillomavirus-16 E6 D25E-Expressing Cell Lines
Virology Journal, 2011 Previously, we have reported that the human papillomavirus (HPV) type 16 E6 D25E is the most prevalent variant in Korean women at high risk for cervical cancers.
Jang Dai-Ho +3 more
doaj +1 more source