Results 41 to 50 of about 32,749 (181)

Humán papillomavírus onkoproteinek hatása celluláris gének expressziójára = Effects of human papillomavirus oncoproteins on the expression of cellular genes [PDF]

, 2009
A genitális humán papillomavírusok (HPV) a méhnyakrák (cervix carcinoma) kialakulásának legfontosabb kockázati tényezői. A survivin fehérje az apoptózis gátlása mellett a sejtosztódás szabályozásában is részt vesz. Tranziens transzfekciós kísérleteinkben,
Murvai, Melinda, Veress, György
core  

Human papillomavirus (HPV) 16 E6 oncoprotein targets the Toll-like receptor pathway

Journal of General Virology, 2018
Cervical cancer is one of the leading causes of death in women worldwide and is etiologically linked to human papillomavirus (HPV) infection. Viral early proteins E6 and E7 manipulate cellular functions to promote the virus life cycle and are essential to the cellular transformation process.
Lucas Boeno, Oliveira, Ismar R, Haga, Luisa Lina, Villa   +2 more
openaire   +2 more sources

Risk of progression of early cervical lesions is associated with integration and persistence of HPV-16 and expression of E6, Ki-67, and telomerase

Journal of Cytology, 2013
Background: Low-grade squamous intraepithelial lesions (LSIL) are the earliest lesions of the uterine cervix, the persistence and integration of high-risk human papillomavirus (HR-HPV) as type 16, which promotes the development of more aggressive lesions.
Arianna Vega-Peña, Berenice Illades-Aguiar, Eugenia Flores-Alfaro, Esther López-Bayghen, Marco Antonio Leyva-Vázquez, Eduardo Castañeda-Saucedo, Luz Del Carmen Alarcón-Romero   +6 more
doaj   +1 more source

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing. [PDF]

, 2012
Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck ...
Barrett, John W, Basmaji, John, Boutros, Paul, Chan-Seng-Yue, Michelle, Dhaliwal, Sandeep, Dowthwaite, Samuel, Franklin, Jason H, Fung, Kevin, Koropatnick, James, Kwan, Keith, Lambin, Philippe, Mymryk, Joe S, Nichols, Anthony C, Palma, David A, Starmans, Maud HW, Szeto, Christopher CT, Todorovic, Biljana, Wehrli, Bret, Xu, Wei, Yoo, John   +19 more
core   +3 more sources

HPV 16 E6 Blocks TNF-Mediated Apoptosis in Mouse Fibroblast LM Cells

Virology, 1999
The interaction between hosts and the viruses that infect them is a dynamic one, and a growing literature documents the fact that many viruses have developed mechanisms designed to avoid elimination by the host immune system. One of the immune strategies used by the host and targeted by virus proteins is apoptosis triggered by the cytokine tumor ...
Duerksen-Hughes, Penelope J., Yang, Jun, Schwartz, Stephanie B.   +2 more
openaire   +2 more sources

Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein Partners

Viruses, 2022
Human papillomavirus type 16 (HPV 16) is the most common oncogenic type of HPV in cervical, anogenital, and head and neck cancers, making HPV 16 an important high-risk HPV (HR HPV) type.
Caylin L. Billingsley, Sreenivasulu Chintala, Rachel A. Katzenellenbogen   +2 more
doaj   +1 more source

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53

Oncology Reports, 2010
The HPV-16 early proteins E6 and E7 are considered to function as oncoproteins in cervical cancer. DNA methyltransferase 1 (DNMT1) is one of the enzymes involved in epigenetic silencing of tumor suppressor genes. In the present study, the functional role and regulation of DNMT1 in HPV-16 E6 associated cervical cancer development were examined ...
Chi Lam, Au Yeung, Wing Pui, Tsang, Tsun Yee, Tsang, Ngai Na, Co, Pak Lun, Yau, Tim Tak, Kwok   +5 more
openaire   +3 more sources

Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]

, 2013
BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R, Darcy, KM, Hatae, M, Kauderer, J, Liao, SY, Nagao, S, Rodgers, WH, Stanbridge, EJ, Susumu, N, Walker, JL   +9 more
core   +1 more source

Biochemical Differences Among Naturally Occurring HPV-16 E6 Variants

Libri oncologici : Croatian journal of oncology, 2018
A number of Human papillomaviruses (HPVs) were shown to be associated with various human cancers. Of these cervical cancer is the most important disease. Whilst the HPV E6 and E7 oncoproteins are responsible for cancer development at different anatomical sites, it is also clear that there are differences of these two oncoproteins among the viral ...
Đukić, Anamaria, Thatte, Jayashree Vijay, Božinović Ksenija, Dediol, Emil, Grce, Magdalena, Banks, Lawrence, Tomaić, Vjekoslav   +6 more
openaire   +3 more sources