Results 51 to 60 of about 32,749 (181)

In VitroAntigene Therapy Targeting HPV-16 E6 and E7 in Cervical Carcinoma

Gynecologic Oncology, 1997
Human papillomavirus (HPV) infection is believed to play a central role in cervical carcinogenesis. Specifically, two viral oncoproteins, E6 and E7, possess transforming ability and have been shown to interact with the cellular tumor suppressors p53 and p105, the retinoblastoma (Rb) gene product.
M, Madrigal, M F, Janicek, B U, Sevin, J, Perras, R, Estape, M, Peñalver, H E, Averette   +6 more
openaire   +2 more sources

HPV 16 E6 promotes growth and metastasis of esophageal squamous cell carcinoma cells in vitro

Molecular Biology Reports, 2021
Abstract BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Increasing evidence has revealed that Human Papillomavirus (HPV) infection may be associated with the possible etiology of ESCC. Nevertheless, the precise role of HPV in ESCC remains unclear.MethodsProliferation and apoptosis capability of ESCC ...
Jiao Jiao Hu, Yu Ji, Ting Ting Miao, Shi Yao Zheng, Xiao Bin Cui, Jian Ming Hu, Lan Yang, Feng Li   +7 more
openaire   +2 more sources

Determining the Molecular Interactions of Natural Inhibitors with the HPV-16 E6 Oncoprotein by Docking and Dynamics Simulation Studies

Brazilian Archives of Biology and Technology
The oncoprotein E6, a pivotal player in HPV-16-induced cancer, has long been the focus of extensive research. Building upon our previous study, we identified asarinin and thiazolo[3,2-a] benzimidazole-3(2H)-one-(2-fluorobenzylideno)-7,8-dimethyl ...
Arief Hidayatullah, Wira Eka Putra, Sustiprijatno, Muhaimin Rifa’i, Muhammad Fikri Heikal, Diana Widiastuti   +5 more
doaj   +1 more source

HPV E6 oncoproteins and nucleic acids in neck lymph node fine needle aspirates and oral samples from patients with oropharyngeal squamous cell carcinoma

Papillomavirus Research, 2018
Commercial assays measuring HPV E6 viral oncoproteins, E6/E7 mRNA or DNA were used to test neck lymph node fine needle aspirates (FNA) and oropharyngeal samples (saliva and oral swabs) from 59 Canadian patients with oropharyngeal squamous cell carcinomas
M. Chernesky, D. Jang, J. Schweizer, M. Arias, L. Doerwald-Munoz, M. Gupta, B. Jackson, S. Archibald, J. Young, A. Lytwyn, M. Smieja, A. Severini, A. Ecobichon-Morris, M. Hyrcza   +13 more
doaj   +1 more source

Prevalence of HPV-DNA and E6 mRNA in lung cancer of HIV-infected patients

Scientific Reports, 2022
HIV-infected individuals could be at a greater risk for developing lung cancer than the general population due to the higher prevalence in the former of human papillomavirus (HPV) in the oral cavity and higher smoking rates.
Guillem Sirera, Sebastián Videla, Verónica Saludes, Eva Castellà, Carolina Sanz, Aurelio Ariza, Bonaventura Clotet, Elisa Martró   +7 more
doaj   +1 more source

Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease [PDF]

, 1995
The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the development of cervical cancers in women infected with certain HPV genotypes, most notably HPV-16 and HPV-18.
Dunn, L. A., Fernando, G. J. P., Frazer, I. H., Lambert, P. F., Leippe, D. M., Liem, A., Phelps, W. C., Tindle, R. W.   +7 more
core  

Exponentially Increasing Incidences of Cutaneous Malignant Melanoma in Europe Correlate with Low Personal Annual UV Doses and Suggests 2 Major Risk Factors [PDF]

, 2015
For several decades the incidence of cutaneous malignant melanoma (CMM) steadily increased in fair-skinned, indoor-working people around the world. Scientists think poor tanning ability resulting in sunburns initiate CMM, but they do not understand why ...
Akslen LA, Beer TM, Chida K, Cornwell ML, Devgun MS, Dianne E Godar, Eisman JA, Elwood JM, European Commission, Frampton RJ, Godar DE, Köstner K, Madhan Subramanian, Robinson ES, Samira Ashrafi, Stephen J Merrill, Tewari A   +16 more
core   +2 more sources

Extracellular calcium regulates keratinocyte proliferation and HPV 16 E6 RNA expression in vitro

APMIS, 2014
Human papillomaviruses (HPV) are known to immortalize oral keratinocytes in vitro, but the underlying mechanisms causing the following resistance to differentiation remain unclear. We investigated the effect of extracellular calcium on the proliferation of HPV16‐positive keratinocytes and on the mRNA expression of the viral E6‐oncogene.
Turunen Aaro Sakari, Syrjänen Stina Marita   +1 more
openaire   +4 more sources

Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survival. [PDF]

PLoS ONE, 2009
BACKGROUND:Human Papillomavirus (HPV)-16 is a paradigm for "high-risk" HPVs, the causative agents of virtually all cervical carcinomas. HPV E6 and E7 viral genes are usually expressed in these tumors, suggesting key roles for their gene products, the E6 ...
Anna M Mileo, Claudia Abbruzzese, Stefano Mattarocci, Emanuele Bellacchio, Paola Pisano, Antonio Federico, Vittoria Maresca, Mauro Picardo, Alessandra Giorgi, Bruno Maras, M Eugenia Schininà, Marco G Paggi   +11 more
doaj   +1 more source

In silico screening and molecular dynamics simulations toward new human papillomavirus 16 type inhibitors

Research in Pharmaceutical Sciences, 2022
Background and purpose: Human papillomavirus (HPV) is known as the main reason for cervical cancer. According to carcinogenic risk, HPV can be located into two classes, counting the low-risk virus, which is the main cause of genital warts and low-grade ...
Nima Razzaghi-Asl, Sahar Mirzayi, Karim Mahnam, Vahed Adhami, Saghi Sepehri   +4 more
doaj   +1 more source