Translational Oncology, 2019 Nearly all cases of cervical cancer are initiated by persistent infection with high-risk strains of human papillomavirus (hr-HPV). When hr-HPV integrates into the host genome, the constitutive expression of oncogenic HPV proteins E6 and E7 function to ...
Zewei Jiang +6 more
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The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. [PDF]
PLoS Pathogens, 2012 A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of hDlg
Vanitha Krishna Subbaiah +6 more
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Efficacy of Combination of Immunotherapies in a Murine in a Murine Squamous Cell Carcinoma Model [PDF]
, 2019 Introduction: Head and neck squamous cell carcinomas (HNSCCs) are a type of neoplasm found in the epithelium of the oral cavity, oropharynx, nasopharynx, larynx, or hypopharynx.
Correia, E. +2 more
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Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: To examine the relationship between human papillomavirus (HPV) and Epstein-Barr virus (EBV) infections in relation to age of patients with cervical adenocarcinoma.
Hei-Yu Lau +6 more
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Expresión de Pirin en tumores de distintas localizaciones anatómicas y su relación con la presencia del virus papiloma humano (HPV) [PDF]
, 2015 Tesis (Tecnólogo Médico, mención morfofisiopatología y citodiagnóstico)En Chile, el cáncer es una patología muy relevante ocupando el segundo lugar como causa de muerte en la población.
Altamirano Pérez, Macarena Natalia +1 more
core
Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells [PDF]
, 2011 Background: Specific types of high risk Human papillomaviruses (HR-HPVs) particularly, HPV types 16 and 18 cause cervical cancer and while the two recently developed vaccines against these HPV types are prophylactic in nature, therapeutic options for ...
Sutapa Mahata +5 more
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Kinetic selection of HPV 16 E6/E7-directed antisense nucleic acids: anti-proliferative effects on HPV 16-transformed cells [PDF]
Nucleic Acids Research, 1999 The E6/E7-coding sequences of the human papillomavirus type 16 (HPV 16) were probed for kinetic accessibility in vitro by pools of catalytic antisense RNA. Only long-chain complementary RNA and very few antisense sequences with a 3' portion complementary to a 10 nt window within unspliced and spliced E6-coding target sequences showed fast annealing ...
F, Venturini +4 more
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Identification of human papillomavirus DNA in cutaneous lesions of Cowden syndrome [PDF]
, 2003 Background: Cowden syndrome (CS) or multiple hamartoma syndrome is a cancer-associated genodermatosis inherited in an autosomal dominant pattern. One of the diagnostic criteria is facial papules which are felt to be trichilemmomas, benign hair follicle ...
Burgdorf, Walter H. C. +4 more
core +1 more source
PLoS Pathogens, 2016 The high-risk Human Papillomavirus (HPV) E6 oncoproteins are characterised by the presence of a class I PDZ-binding motif (PBM) on their extreme carboxy termini.
Miranda Thomas +4 more
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Conformational Dynamics and Disorder of HPV-16 E6
Abstract Persistent infection with high-risk human papillomavirus (HPV) types, notably HPV-16, drives oncogenesis through the multifunctional E6 oncoprotein (16E6), which hijacks host regulatory pathways by engaging diverse protein partners. Despite extensive structural characterization of 16E6 in complex with host targets, the intrinsic dynamics of ...
Liam Kwak, Roberto A. Garza-López
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