PLoS ONEHuman Papilloma Virus type 16 (HPV-16) is highly oncogenic with the E6 and E7 oncogenes playing crucial roles in the pathogenesis of HPV-related cervical carcinogenesis.
Saima Younas +6 more
doaj +1 more source
How human papillomavirus replication and immune evasion strategies take advantage of the host DNA damage repair machinery [PDF]
, 2017 The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation.
Bordignon, Valentina +8 more
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Effect of Preanalytical Processing of ThinPrep Specimens on Detection of High-Risk Human Papillomavirus by the Aptima HPV Assay [PDF]
, 2014 Two important preanalytical protocols performed on liquid-based cytological specimens, namely, automated cytology processing and glacial acetic acid (GAA) treatment, may occur prior to the arrival of specimens in a molecular diagnostics laboratory ...
Amrhein, Robert D. +7 more
core +2 more sources
Journal of Biomedical Science, 2005 Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant transformation of HPV-associated lesions. Thus, E6 and E7 represent ideal targets for therapeutic HPV vaccine development. We have previously used the gene gun approach to test several intracellular targeting and intercellular spreading strategies ...
Shiwen, Peng +7 more
openaire +2 more sources
p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein
Virology Journal, 2008 Background Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not ...
Morgan Iain M +4 more
doaj +1 more source
Genome editing technologies to fight infectious diseases [PDF]
, 2017 Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa +2 more
core +1 more source
Felis catus papillomavirus type 2 infection and skin cancer in domestic cats : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Massey University, Manawatū, New Zealand [PDF]
, 2016 Felis catus papillomavirus type 2 (FcaPV-2) is a virus which commonly infects the skin of domestic cats. While most infections are asymptomatic, there is growing evidence that FcaPV-2 may play a role in the development of a subset of feline cutaneous ...
Thomson, Neroli Anne
core
Molecular analysis of the interaction between HPV type 16 E6 and human E6‐associated protein
FEBS Letters, 1997 The complex formed between the human papillomavirus type 16 E6 protein and human E6‐associated protein, which combine to ubiquitylate and degrade p53, has been studied by chemical crosslinking. Analysis of the interactions of proteins purified from Escherichia coli as well as proteins expressed in insect cells indicates that, while E6 has the capacity ...
Daniels, P.R. +3 more
openaire +2 more sources
Untangling the Most Probable Role for Vitamin D\u3csub\u3e3\u3c/sub\u3e in Autism [PDF]
, 2017 Recent studies indicate an important role for vitamin D3 in autism spectrum disorder (ASD), although its mechanism is not completely understood.
Godar, Dianne E., Merrill, Stephen J.
core +1 more source