Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis. [PDF]
Mol Neurodegener, 2016 Background Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein.
Lim SM +14 more
europepmc +6 more sources
Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis. [PDF]
Arthritis Res Ther, 2019 Background Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in rheumatoid arthritis patients ...
Eustace AD +8 more
europepmc +6 more sources
Topical Application of Adult Cecal Contents to Eggs Transplants Spore-Forming Microbiota but Not Other Members of the Microbiota to Chicks. [PDF]
Appl Environ Microbiol, 2020 International audienceThe intestinal microbiota plays an essential role in the metabolism and immune competence of chickens from the first day after hatching.
Richards-Rios P +4 more
europepmc +6 more sources
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model. [PDF]
Toxins (Basel)Snakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poorly ...
Alsolaiss J +7 more
europepmc +8 more sources
Semi-parametric Expected Shortfall Forecasting [PDF]
, 2014 Intra-day sources of data have proven effective for dynamic volatility and tail risk estimation. Expected shortfall is a tail risk measure, that is now recommended by the Basel Committee, involving a conditional expectation that can be semi ...
Albertson, D.G. +14 more
core +5 more sources
Value-at-risk and extreme value distributions for financial returns [PDF]
, 2008 The ability of the Generalised Extreme Value (GEV) and Generalised Logistic (GL) distributions to fit extreme financial returns in the stock, commodities and bond markets is assessed. The empirical results indicate that the too much celebrated GEV is not
Tolikas, K
core +2 more sources
Quadcopter based emergency medikit delivery system for hill stations [PDF]
, 2020 Nowadays UAV’s are more common for search, rescue and surveillance. A quadcopter UAV system is proposed to be used for aerial transportation of medicine. A Quadcopter has a drive chassis having a propeller, ESC, motor, frames and battery. The quadcopter
Balamurugan, C. R. +2 more
core +2 more sources
Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom [PDF]
, 2022 Snakebite envenoming was reintroduced as a Category A Neglected Tropical Disease by the World Health Organization in 2017. Since then, increased attention has been directed towards this affliction and towards the development of a deeper understanding of ...
Ahmadi, Shirin +12 more
core +4 more sources
Reinventing mutualism between humans and wild fauna: insights from vultures as ecosystem services providers [PDF]
, 2012 In parallel with economic and social changes, mutualism in human-vulture relations has virtually disappeared worldwide. Here, we describe the mutualistic relationship between humans and the globally threatened Egyptian vulture in Socotra, Yemen.
Gangoso, Laura +6 more
core +1 more source
Ranking of VaR and ES Models: Performance in developed and emerging markets [PDF]
, 2012 An inherent problem with comparing and ranking competing Value at Risk (VaR) and Expected shortfall (ES) models is that they measure only a single realization of the underlying data generation process.
Filer, Randall, Zikovic, Sasa
core