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Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes [PDF]

Applied Microbiology and Biotechnology, 2014
Lysobacter species are emerging as new sources of antibiotics. The regulation of these antibiotics is not well understood. Here, we identified a small molecule metabolite (LeDSF3) that regulates the biosynthesis of the antifungal antibiotic heat-stable antifungal factor (HSAF), a polycyclic tetramate macrolactam with a structure and mode of action ...
Fengquan Liu, Gary Yuen, Yuemao Shen
exaly   +3 more sources

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Biosynthesis of Odd-Carbon Unsaturated Fatty Dicarboxylic Acids Through Engineering the HSAF Biosynthetic Gene in Lysobacter enzymogenes

Molecular Biotechnology, 2022
Fatty dicarboxylic acids (FDCA) are useful as starting materials or components for plastics, polyesters, nylons, and fragrances. Most of the commercially available FDCA contain an even number of carbons, and there remain few sustainable methods for production of FDCA with an odd number of carbons (o-FDCA). In this work, we explored a novel biosynthetic
Vimmy Khetrapal, Patrick Dussault, Liangcheng Du   +2 more
openaire   +2 more sources

3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3†‡

MedChemComm, 2012
HSAF isolated from Lysobacter enzymogenes is an antifungal natural product with a new mode of action. The polycyclic tetramate macrolactam (PTM) carries a 3-hydroxyl group on the ornithine residue, which is a feature common to nearly all PTM type natural products found in phylogenetically diverse organisms.
Yuemao Shen, Yaoyao Li, Liangcheng Du
exaly   +2 more sources

Using the Jupyter Notebook as a Tool for analyzing the EUMETSAT HSAF snow products

2020
<p>Snow cover is an essential climate variable directly affecting the Earth’s energy balance, therefore estimating the snow parameters play an important role in hydrological, land surface, meteorological and climate models.
Zuhal Akyurek, Kenan Bolat, Cagri Hasan Karaman, Matias Takala   +3 more
openaire   +1 more source

Harmonic elimination in single phase systems by means of a hybrid series active filter (HSAF)

2010 1st Power Electronic & Drive Systems & Technologies Conference (PEDSTC), 2010
In this paper, a fully-digital-controlled hybrid series active filter (HSAF) for harmonic elimination and reactive power compensation in single phase systems is presented. The HSAF is composed of two single tuned LC filters and a small-rated active filter. Discrete Fourier transformation is used as the control method.
Mehdi Salehifar, Hossein Ali Mohammadpour, Amir Hassan Moghadasi, Abbas Shoulaie   +3 more
openaire   +1 more source

Control of cyst nematodes by Lysobacter enzymogenes strain C3 and the role of the antibiotic HSAF in the biological control activity

Biological Control, 2018
Abstract Lysobacter enzymogenes C3, a bacterial biocontrol agent of fungal and oomycetous plant pathogens, produces an antimicrobial secondary metabolite complex (HSAF) as a mechanism for its antifungal activity. In this study, strain C3 was investigated for its activity against various life history stages of Heterodera schactii, the sugarbeet cyst ...
Gary Y. Yuen, Kyle C. Broderick, Charlene C. Jochum, Carl J. Chen, Edward P. Caswell-Chen   +4 more
openaire   +1 more source

Assessing the snow cover dynamics and monitoring the anomalies in snow-covered days for paneuropean region using eumetsat hsaf snow products

2023
The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)
Kuter, S., Karaman, C., Akpınar, M., Akyurek, Z.   +3 more
openaire   +2 more sources

Function of a pathway-associated major facilitator superfamily gene hsaf-orf1 in the biosynthesis of the antifungal HSAF in Lysobacter enzymogenes

Tetrahedron, 2023
Huan Yue, Liangcheng Du
openaire   +1 more source

The natural polycyclic tetramate macrolactam HSAF inhibit Fusarium graminearum through altering cell membrane integrity by targeting FgORP1

International Journal of Biological Macromolecules
Fusarium graminearum is a dominant phytopathogenic fungus causing Fusarium head blight (FHB) in cereal crops. Heat-stable antifungal factor (HSAF) is a polycyclic tetramate macrolactam (PoTeM) isolated from Lysobacter enzymogenes that exhibits strong antifungal activity against F. graminearum. HSAF significantly reduces the DON production and virulence
Wenchan, Chen, Bao, Tang, Rongxian, Hou, Weibo, Sun, Chenyang, Han, Baodian, Guo, Yangyang, Zhao, Chaohui, Li, Cong, Sheng, Yancun, Zhao, Fengquan, Liu   +10 more
openaire   +2 more sources

HSAF Workshop 25 January 2022: Presentation by Ján Kaňák

2023
Kaňák, Jan, Sk, Luboslav Okon@Shmu, Méri, Ladislav, Kateřina Hrušková, Zvolenský, Marcel, Madara, Martin   +5 more
openaire   +1 more source