Results 81 to 90 of about 593 (166)

Studies on the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF and the AMPK-activating mycoepoxydiene

, 2013
In search for antifungal compounds with novel chemistry and a new mode of action, we isolated a heat stable antifungal factor (HSAF) from Lysobacter enzymogenes C3.
Xie, Yunxuan
core  

Molecular Mechanism for the Biosynthesis of Antifungal HSAF and Antibacterial WAP-8294A2 [PDF]

, 2015
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soil and water, such as the Gram-negative, prolific producers of natural products, Lysobacter, remain largely unexplored. This PhD thesis reports our studies
Chen, Haotong
core  

Unusual Activities of the Thioesterase Domain for the Biosynthesis of the Polycyclic Tetramate Macrolactam HSAF in Lysobacter enzymogenes C3

, 2016
HSAF is an antifungal natural product with a new mode of action. A rare bacterial iterative PKS-NRPS assembles the HSAF skeleton. The biochemical characterization of the NRPS revealed that the thioesterase (TE) domain possesses the activities of both a ...
Ronald L. Cerny (1961758), Lili Lou (2128960), Haotong Chen (2128957), Yaoyao Li (425792), Yuemao Shen (138504), Liangcheng Du (425795)   +5 more
core   +1 more source

Structure and activity of apoferritin-stabilized gold nanoparticles

, 2007
A simple method for synthesizing gold nanoparticles stabilized by horse spleen apoferritin (HSAF) is reported using NaBH4 or 3-(N-morpholino)propanesulfonic acid (MOPS) as the reducing agent.
Butts, Christopher A., Yerubandi, Vijay, Dmochowski, Ivan J., Swift, Joe; id_orcid, Zhang, Lei   +4 more
core   +5 more sources

Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310 [PDF]

, 2014
Peer ...
Sazak, Anil, Anil Sazak, Houssen, Wael E, Jioji Tabudravu, Kwaku Kyeremeh, Hai Deng, Kyeremeh, Kwaku, Kojo Acquah, Deng, Hai, Tabudravu, Jioji, Marcel Jaspars, Acquah, Kojo, Houssen, Wael, Jaspars, Marcel, Wael Houssen   +14 more
core   +1 more source

Biosynthetic Engineering and Molecular Regulation of Bioactive Natural Products in Lysobacter enzymogenes

, 2022
Microbial natural products are one of the best sources for production of novel antibiotics, anticancer agents and immunosuppressants. Due to the persistent evolution of drug-resistant pathogens, the identification of novel antibiotics is extremely ...
Khetrapal, Vimmy
core  

MOESM1 of LesR is a novel upstream regulator that controls downstream Clp expression to modulate antibiotic HSAF biosynthesis and cell aggregation in Lysobacter enzymogenes OH11

, 2017
Additional file 1. Table S1. Primers used in this study. Table S2. Genes controlled by LesR in Lysobacter enzymogenes. Figure S1. LeDSF signaling did not control the Clp protein level.
Huiyong Xu, Ruping Wang, Yangyang Zhao, Fu, Zheng Qing, Guoliang Qian, Fengquan Liu   +5 more
openaire   +1 more source

Biological Functions of Polycyclic Tetramate Macrolactams from Lysobacter enzymogenes

, 2022
Lysobacter species are gliding Gram-negative bacteria and prolific producers of new bioactive natural products which are largely underexplored. So far, several classes of structurally distinct and biologically active natural products have been isolated ...
Yue, Huan
core  

Biosynthetic mechanism for polyketide-derived mycotoxin fumonisins and antimycotic HSAF

, 2012
Polyketides are a large group of natural products produced by microorganisms and plants. Polyketides exhibit a staggering range of medicinally important activities, including antibiotic, anticancer, antifungal, antiparasitic, and immunosuppressive ...
Huffman, Justin M
core  

Data Assimilation of Satellite-Derived Rain Rates Estimated by Neural Network in Convective Environments: A Study over Italy

Remote Sensing
The accurate prediction of heavy precipitation in convective environments is crucial because such events, often occurring in Italy during the summer and fall seasons, can be a threat for people and properties.
Rosa Claudia Torcasio, Mario Papa, Fabio Del Frate, Alessandra Mascitelli, Stefano Dietrich, Giulia Panegrossi, Stefano Federico   +6 more
doaj   +1 more source