Results 51 to 60 of about 13,949 (177)

The MHC-II Transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

Frontiers in Microbiology, 2013
The activation of CD4+ T helper cells is strictly dependent on the presentation of antigenic peptides by MHC Class II molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (Class II ...
Greta eForlani, Rawan eAbdallah, Roberto S Accolla, Giovanna eTosi   +3 more
doaj   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 795-806, August 2026.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Trends in Mortality After the Roll‐Out of Directly Acting Antivirals for Hepatitis C in England Using Linked Surveillance Data

Journal of Viral Hepatitis, Volume 33, Issue 8, August 2026.
ABSTRACT Directly acting antivirals (DAAs) revolutionised hepatitis C virus (HCV) treatment, offering higher cure rates. We aimed to quantify life expectancy (LE) differences between treated and untreated individuals diagnosed with HCV and assess the contributions of age and causes of death to these differences.
David Etoori, Ruth Simmons, Annabel Powell, Monica Desai, Paul Trembling, Caroline Sabin, William Rosenberg   +6 more
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1310-1324, July 2026.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Cadernos de Saúde Pública, 2003
We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984.
Kazanji Mirdad, Gessain Antoine
doaj  

IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers.

PLoS Neglected Tropical Diseases, 2014
BackgroundThe polymorphisms of IL28B have been described as important in the pathogenesis of infections caused by some viruses. The aim of this research was to evaluate whether IL28B gene polymorphisms (SNP rs8099917 and SNP rs12979860) are associated ...
Tatiane Assone, Fernando Vieira de Souza, Karen Oliveira Gaester, Luiz Augusto Marcondes Fonseca, Olinda do Carmo Luiz, Fernanda Malta, João Renato Rebello Pinho, Fernanda de Toledo Gonçalves, Alberto Jose da Silva Duarte, Augusto Cesar Penalva de Oliveira, Jorge Casseb   +10 more
doaj   +1 more source

Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study

Retrovirology, 2004
Background HTLV-I is associated with adult T-cell leukemia, and both HTLV-I and -II are associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Smith James W, Garratty George, Nass Catharie C, Wright David J, Wang Baoguang, Orland Jennie R, Newman Bruce, Smith Donna M, Murphy Edward L   +8 more
doaj   +1 more source

Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1

Retrovirology, 2019
Background Immunity against pathogens evolved through complex mechanisms that only for sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and adaptive immunity are strongly intertwined each other during evolution.
Greta Forlani, Mariam Shallak, Elise Ramia, Alessandra Tedeschi, Roberto S. Accolla   +4 more
doaj   +1 more source

Expression and purification of recombinant HTLV-I/-II linear epitopes antigen and its application for screening of suspected patients

Iranian Journal of Microbiology, 2017
Background and Objectives: The linear epitopes of gp46-I, gp46-II, gp21 and p19 are used in diagnosis of HTLV-I/-II infections. The aims of this study was to obtain high-level expression and purification of recombinant antigen (RA) containing these ...
Roxana Faramarzi, Samaneh Dolatabadi
doaj  

First report on human T-lymphotropic virus 1 infection in a group of transgender women

Frontiers in Public Health
IntroductionThere is a lack of data on human T-lymphotropic virus 1 (HTLV-1) infection among transgender women (TGW). Therefore, this study estimated the prevalence of HTLV-1 infection in a group of TGW in Brazil.MethodsA cross-sectional study was ...
Megmar Aparecida dos Santos Carneiro, Mykaella Cristina Araújo Margarida, Bruno Vinícius Diniz e Silva, Ágabo Macedo da Costa e Silva, Márcia Alves Dias de Matos, Karlla Antonieta Amorim Caetano, Sheila Araújo Teles, Antonio Carlos Rosário Vallinoto, Regina Maria Bringel Martins   +8 more
doaj   +1 more source