Results 31 to 40 of about 8,869 (179)

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

Endothermy, neuron counts, and other issues: Further remarks on neurocognitive evolution in fossil vertebrates

The Anatomical Record, EarlyView.
Abstract Last year, we challenged the view that large‐bodied theropod dinosaurs such as Tyrannosaurus rex resembled primates in cognition and behavior, a proposition made by Herculano‐Houzel in 2023. More recently, Jensen et al. have criticized our work on this topic, raising methodological and conceptual issues.
Kai R. Caspar, Cristián Gutiérrez‐Ibáñez, Hady George, Thomas R. Holtz Jr., Darren Naish, Grant R. Hurlburt   +5 more
wiley   +1 more source

Knowledge translation and health technology reassessment: identifying synergy

BMC Health Services Research, 2018
Background Health Technology Reassessment (HTR) is an emerging field that shifts the focus from traditional methods of technology adoption to managing technology throughout its lifecycle.
Rosmin Esmail, Heather Hanson, Jayna Holroyd-Leduc, Daniel J. Niven, Fiona Clement   +4 more
doaj   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Knee height is often right: evaluating device height effects on camera trapping rate

Remote Sensing in Ecology and Conservation, EarlyView.
Camera trap deployment height can introduce systematic biases in detection trapping rates across species of different body sizes. Combining 172 paired sampling points in five experiments across Europe, North America and Africa, our results show that low cameras significantly increase detections of small‐ and medium‐sized species, whereas high cameras ...
Jorge Sereno‐Cadierno, Tim R. Hofmeester, Marcus Becker, Alice Bernard, Lizette Moolman, Hervé Fritz, Pelayo Acevedo   +6 more
wiley   +1 more source

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

eLife, 2016
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways.
Jacob M Vogan, Xiaozhu Zhang, Daniel T Youmans, Samuel G Regalado, Joshua Z Johnson, Dirk Hockemeyer, Kathleen Collins   +6 more
doaj   +1 more source

Gas check prevention during calendering of poly(vinyl chloride) films using poly(caprolactone)‐based additives

Journal of Vinyl and Additive Technology, Volume 31, Issue 2, Page 441-452, March 2025.
Three poly(caprolactone) (PCL)‐based additives of differing molecular weights were used as a secondary plasticizer to prevent gas checks in PVC films produced through calendering. Results showed that chemical and physicochemical properties influence the prevention or reduction of gas checks, unlike rheological properties including complex viscosity and
Luis F. Alvarez, Kushal Panchal, Richard L. Leask, Milan Maric, Jim A. Nicell   +4 more
wiley   +1 more source

Workshop HTR-United: metadata, quality control and sharing process for HTR training data

, 2023
This workshop uses the environment created around the HTR-United catalog to demonstrate and discuss how to build a dataset of ground truth for text recognition and document it, and how to use HTR-United and its suite of tools to control its quality and describe it in a standardized way.
Clérice, Thibault, Chagué, Alix
openaire   +1 more source

Eco‐evolutionary dynamics of partially migratory metapopulations in spatially and seasonally varying environments

Journal of Animal Ecology, EarlyView.
Partial seasonal migration is rarely considered in a metapopulation context. Here, Haaland et al. use an eco‐evolutionary model revealing how partially migratory metapopulations may arise and be maintained, and how seasonal migrants may cause effects of local extreme climatic events to percolate through metapopulations across diverging temporal and ...
Thomas R. Haaland, Ana Payo‐Payo, Paul Acker, Rita Fortuna, Sarah J. Burthe, Irja I. Ratikainen, Francis Daunt, Jane M. Reid   +7 more
wiley   +1 more source