Results 81 to 90 of about 1,691,355 (237)

Integrated multi-omics reveals the relationship between growth performance, rumen microbes and metabolic status of Hu sheep with different residual feed intakes

Animal Nutrition
Residual feed intake (RFI) is a metric that provides a more accurate measure of feed efficiency. The lower the RFI, the higher the feed efficiency. The changes in the host microbiome and metabolome contribute to the greater feed efficiency of low RFI ...
Yanzhen Zhang, Xiaowei Zhang, Dingren Cao, Jinyong Yang, H. Mao, Lingling Sun, Chong Wang   +6 more
semanticscholar   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Efficient and Specific Generation of MSTN-Edited Hu Sheep Using C-CRISPR

Genes, 2023
Hu sheep, an indigenous breed in China known for its high fecundity, are being studied to improve their growth and carcass traits. MSTN is a negative regulator of muscle development, and its inactivation results in muscularity. The C-CRISPR system, utilizing multiple neighboring sgRNAs targeting a key exon, has been successfully used to generate genes ...
Rihong Guo, Huili Wang, Chunhua Meng, Hongbing Gui, Yinxia Li, Fang Chen, Chenjian Zhang, Han Zhang, Qiang Ding, Jianli Zhang, Jun Zhang, Yong Qian, Jifeng Zhong, Shaoxian Cao   +13 more
openaire   +2 more sources

Improving stress coping ability: comparison between the CYP17 genotype Of Ovis Aries and Capra Hircus [PDF]

, 2010
The ability of animals to adapt to stress is not only an animal health and welfare concern, but also influences reproduction potential and robustness. An important pathway involved in the stress response is the hypothalamic-pituitary-adrenal axis (HPAA ...
Cloete, S.W.P., Hough, D., Storbeck, K., Swart, P.   +3 more
core  

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Giardia duodenalis in Hu sheep: occurrence and environmental contamination on large-scale housing farms

Parasite, 2023
Giardia duodenalis is a common zoonotic intestinal parasitic protozoan and sheep are among its hosts; however, limited information is available on sheep kept in large-scale housing.
Zhao Qianming, Lu Chenyang, Pei Zhiyang, Gong Pihong, Li Junqiang, Jian Fuchun, Jing Bo, Qi Meng, Ning Changshen   +8 more
doaj   +1 more source

Live yeast (Saccharomyces cerevisiae) improves growth performance and liver metabolic status of lactating Hu sheep.

Journal of Dairy Science
Yeast, a natural starter culture, is widely used to improve digestion function in ruminants. However, whether yeast affects the physiological state of the liver in ruminants is currently unknown.
Shendong Zhou, Jie Huang, Hao Zhang, Xiaokun Song, Yijin Jiang, Xu Zhao, Xiangzhen Shen   +6 more
semanticscholar   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Candidate genes for the development of hair follicles in Hu sheep

Genetics and Molecular Research, 2016
The aim of this study was to detect candidate genes for the development of hair follicles in the Hu sheep breed. Seven genes have been detected in large, medium, and small wave follicles of Hu sheep using gene chip technology. The histological features of the follicles of newborn Hu-lambs were combined with fluorescence quantitative PCR technology to ...
X Y, Lv, R, Ni, W, Sun, R, Su, H H, Musa, J F, Yin, Q Z, Wang, W, Gao, L, Chen   +8 more
openaire   +2 more sources

Genome-wide selection reveals candidate genes associated with multiple teats in Hu sheep

Animal Biotechnology
Increasing the number of teats in sheep helps to improve the survival rate of sheep lambs after birth. In order to analyze the candidate genes related to the formation of multiple teats in Hu sheep, the present study was conducted to investigate the ...
Wen Zhou, Cheng-long Zhang, Zhipeng Han, Xiaopeng Li, Xinyu Bai, Jieru Wang, Ruizhi Yang, Shudong Liu   +7 more
doaj   +1 more source