Results 111 to 120 of about 392,674 (301)
Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation
Advanced Healthcare Materials, EarlyView.This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad +7 more
wiley +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Advanced Healthcare Materials, EarlyView.This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source
Using Multi-hub Structures for international R&D Organizational Inertia and the Challenges of Implementation [PDF]
Over the last decade or so, multinational enterprises (MNEs) have shifted from centralised hub structures to multi-hub structures. While these new structures provide greater potential for crossfertilization of technologies and access to location-specific
Paola Criscuolo, Rajneesh Narula
core
Hub facility location with fixed costs
Papers in Regional Science, 1992 In thep-hub location model, it is usual to ignore the fixed costs of opening facilities. In contrast, the simple plant location problem includes fixed facility costs and thereby makes thenumber of facilities one of the decision variables. This paper introduces fixed facility costs into a hub location model, thereby making the number of hubs a decision ...
openaire +1 more source
Advanced Healthcare Materials, EarlyView.This study relies on the development of a new sensor that can detect two closely related proteins involved in Alzheimer's disease at the same time. Unlike traditional methods, it works in natural conditions and does not require sample pretreatment. The device is highly sensitive and was successfully tested on patient samples, offering promises for ...
Giulia Siciliano +12 more
wiley +1 more source
A dynamic Median Multiple Allocation hub Location Problem
مدیریت تولید و عملیات, 2015 Hub location problem is further used in transportation and telecommunication networks (airlines, post delivery services, etc.) so origin-destination pairs, receive or send commodities via special facilities called Hub.
Mahdi Bashiri, Khosro Hamidian
doaj
Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells
Advanced Materials, EarlyView.This study demonstrates plasmonic enhancement of the function of fluorescent voltage sensing proteins (genetically encoded voltage indicators, (GEVIs), QuasAr6) in live mammalian cells. Coupling to plasmonic nanoparticles does not just increase fluorescence, but influences the protein photocycle, creating a hybrid sensor with its response speed to ...
Marco Locarno +16 more
wiley +1 more source
International Journal of Industrial Engineering and Production Research, 2016 This paper presents a bi-objective capacitated hub arc location problem with single assignment for designing a metro network with an elastic demand. In the literature, it is widely supposed that the network created with the hub nodes is complete. In this
Firoozeh Kaveh +3 more
doaj