Results 241 to 250 of about 389,511 (307)

The effect of different initial solutions on the metaheuristic algorithms for the single allocation p-hub center and routing problem. [PDF]

PeerJ Comput Sci
Kassoumeh AK, Kartal Z, Arslan A.
europepmc   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Atypical Location of a Complex Odontoma in an 11-Year-Old Girl: A Case Report With a 2-Year Follow-Up. [PDF]

Clin Case Rep
Zalane M, Moulart C, Evrard L, Fallas J, Vilbi M, Dahdouh N.   +5 more
europepmc   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Development of an mHealth App Prototype for LGBTQIA+ Individuals' Sexual and Reproductive Health in Gauteng Province, South Africa: Design Science Research Study. [PDF]

JMIR Form Res
Seretlo RJ, Mokgatle MM, Smuts H, Sepeng NV.   +3 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Tele-Intensive Care Unit-associated Early Recognition of In-hospital Hemodynamic Events and Clinical Outcomes: A Multicenter Observational Study. [PDF]

Indian J Crit Care Med
Dharanindra M, Potineni RB, Rayana S, Thommandru S, Shaik J, Jampala K, Kakumanu LS, Uppalapati ST, Nallapaneni SC, Madduri VK, Yalavarthi KC.   +10 more
europepmc   +1 more source

High-dimensional co-expression network analysis reveals persistent TRH gene expression throughout axolotl telencephalon regeneration. [PDF]

Front Bioinform
Gómez-Morales I, Mendizabal-Ruiz AP, Morales JA, Romero-Gutiérrez T.   +3 more
europepmc   +1 more source

Efficacy and economic impact of a WeChat-based integrated care model for pulmonary rehabilitation in COPD: a retrospective propensity score matched study. [PDF]

BMC Pulm Med
Zheng Q, Zhou X, Jiang P, Pan Q, Chen W.
europepmc   +1 more source