Results 151 to 160 of about 402,413 (320)

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Redox‐Active NiOx‐Catalyzed Li+ Capture‐Extraction Strategy for tBP‐Free Spiro‐OMeTAD Enables Exceptional Damp‐Heat Stability in Perovskite Solar Cells

Advanced Science, EarlyView.
The redox‐active nature of NiOx enables ultrafast oxidative doping of spiro‐OMeTAD within seconds. Concurrently, NiOx‐Li+ coordination complexes formed during this redox process are selectively removed by filtration, effectively extracting residual Li+ ions from the film.
Yun Seop Shin, Minjin Kim, Jaehwi Lee, Chang Hyeon Yoon, Jongdeuk Seo, Gyeong‐Cheon Choi, Sujung Park, Min Jung Sung, Kyungnan Son, Sungjun Hong, Inyoung Jeong, Junseop Byeon, Yimhyun Jo, Dongmin Lee, Minseong Kim, Shinuk Cho, Ji‐Youn Seo, Jin Young Kim, Dong Suk Kim, SeJin Ahn   +19 more
wiley   +1 more source

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source

Photo‐Responsive Room‐Temperature Phosphorescent Films Exhibiting Photochromism and Time‐Dependent Phosphorescent Colors for Multilevel Anti‐Counterfeiting

Advanced Science, EarlyView.
A series of photo‐responsive polymers are prepared by a facile one‐pot in situ synthesis strategy, where RTP modules and photochromic units are systematically integrated into one polymer system. The triplet‐singlet Förster resonance energy transfer (TS‐FRET) between the donor and acceptor enables the material to exhibit time‐dependent phosphorescence ...
Ziyi Bai, Xinyi Xu, Jinbo Fu, Di Zhao, Yige Wang, Huanrong Li   +5 more
wiley   +1 more source

Evaluating the initial result of transanal and transvaginal NOTES for colorectal cancer

Vietnam Journal of Science, Technology and Engineering, 2017
Objective: Natural Orifice Transluminal Endoscopic Surgery (NOTES) is an important evolution in minimally invasive surgery (MIS) nowaday. This paper presents the techniques and early results of the pure transanal and transvaginal laparoscopies (NOTES ...
Nhu Hiep Pham, Huu Thien Ho, Anh Vu Pham, Hai Thanh Phan, Thanh Xuan Nguyen, Xuan Dong Pham, Tien Nhan Van, Nghiem Trung Tran, Trung Vy Pham, Si Doan Diem Tran, Trung Hieu Mai, Le Minh Chau Dao   +11 more
doaj  

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Rapid Room‐Temperature Synthesis of Te4+‐Doped Cs2ZrCl6 Vacancy‐Ordered Double Perovskites With Tunable Luminescence Triggered by Extreme Conditions for Advanced Optical Thermometry and Manometry

Advanced Science, EarlyView.
Through utilizing a proposed rapid room‐temperature precipitation method, the Te4+‐doped Cs2ZrCl6 vacancy‐ordered doubles with intense STE emission were synthesized. Via using the extreme conditions, i.e., temperature and pressure, stimulus, the luminescence properties of the resulting compounds are significantly modulated, endowing their promising ...
Zhiyu Pei, Yeshan Wu, Shuailing Ma, Tian Cui, Laihui Luo, Peng Du   +5 more
wiley   +1 more source

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source

Hues and cry [PDF]

Nature, 2015
openaire   +2 more sources