Results 111 to 120 of about 12,389,112 (241)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluation of the effects of daily husbandry practices on the prevention and progression of canine cognitive dysfunction syndrome

Human-Animal Interactions
This study aimed to identify daily husbandry factors associated with reduced incidence and progression of cognitive dysfunction syndrome (CDS) without incurring treatment expenses.
Nana Ushine, Hiroko Otsubo, Takashi Shimizu, Masahisa Watarai   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The mediating effect of attachment to pets in the association between attachment styles and satisfaction with life among a sample of Lebanese adults

Human-Animal Interactions
Background: Attachment to animals is increasingly recognized as a widespread phenomenon, as the human-animal relationship has been shown to enhance mental health and well-being.
Aline Ghosn, Rita Daher, Jane Ziade, Diana Malaeb, Souheil Hallit, Sahar Obeid   +5 more
doaj   +1 more source

Integrative Model of Human-Animal Interactions: A One Health-One Welfare Systemic Approach to Studying HAI. [PDF]

Front Vet Sci, 2022
Leconstant C, Spitz E.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Feline events beyond pet ownership paradigm: An ethnographic case report on end-of-life decision-making for NONAME 6796

Human-Animal Interactions
Background: The human–animal bond is most often understood within the framework of the “pet ownership paradigm,” which defines a permanent relationship between an animal and their legal guardian.
Burak Taşdizen
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Palliation of a Juvenile Canine with dilated cardiomyopathy: A case report on the human-animal bond

Human-Animal Interactions
Background: Veterinary hospice and palliative care for juvenile patients present unique clinical and emotional challenges. This case report describes the end-of-life journey of “Ollie”, a 16-month-old English Setter diagnosed with dilated cardiomyopathy (
Dr Laura McGuffog
doaj   +1 more source