Results 41 to 50 of about 649,693 (260)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Wildlife Society Bulletin, 2015 ABSTRACT From 1995 to 1997, black bears ( Ursus americanus ) involved in conflicts with humans in southeastern Colorado, USA, were radiocollared, translocated, and monitored by the Colorado Division of Wildlife to evaluate ...
Mat W. Alldredge +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The Health Consequences of Mozambican Civil War : an Anthropometric Approach [PDF]
Survivors are the ones who bear the burden of reconstruction, thus the examination of the costs of civil conflicts to survivors health is crucial for the design of post-war economic policies. This paper investigates this question for the Mozambican civil
Patrick Domingues
core
The Sustainable Livelihoods Approach [PDF]
, 2008 {Excerpt} The sustainable livelihoods approach improves understanding ofthe livelihoods of the poor. It organizes the factors that constrain or enhance livelihood opportunities, and shows how they relate.
Serrat, Olivier
core +1 more source
Late season frosts and changing snowpack may exacerbate human–bear conflicts
EcosphereAbstractThe North American black bear (Ursus americanus) is an opportunistic omnivore that depends on seasonal availability of fruits, nuts, grasses, and forbs for survival. Black bears on the urban–wildland interface also use anthropogenic food resources, especially when natural food resources are scarce.
Kevin T. Shoemaker +7 more
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Romans 7: The Believer\u27s Accountability to the Law [PDF]
, 2009 The most strategic epistle in the NT is the Book of Romans where the clearest and most comprehensive explanation of the gospel and the principles of the Christian life.
Fanning, Don
core +1 more source