Results 161 to 170 of about 455,243 (269)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Applications of Human-Centered Design to Food Is Medicine Interventions: The THRIVE Pilot Trial. [PDF]

J Am Heart Assoc
Adeleye K, McDaniel K, Iribe I, Assani-Uva A, Dugbartey J, Sinyan A, Bhattarai B, DeMarco S, Tomiwa T, Olusola-Bello M, Akubo C, Metlock FE, Kyeremeh D, McMahon A, Kramer-Johansen M, Washington I, Chen P, Rodriguez C, Johnson M, Xiao W, Gledhill S, Yeboah-Manson S, Kurien N, Vassiliadi L, Freeman J, Izquierdo-Porrera AM, Palencia L, Sullivan VK, Commodore-Mensah Y, Ogungbe O, THRIVE Food Is Medicine Team.   +30 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Human-centered evaluation of statistical parametric mapping and explainable machine learning for outlier detection in plantar pressure data. [PDF]

Sci Rep
Dindorf C, Dully J, Simon S, Perchthaler D, Becker S, Ehmann H, Heitmann K, Stetter B, Diers C, Fröhlich M.   +9 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Human-Centered Design to Tailor Telehealth Cardiac Rehabilitation to Diverse Populations: The MCNAIR Study. [PDF]

J Am Heart Assoc
Oanesa RD, Atluri N, Boyd A, Khoury SR, Legeza V, Merritt JG, McNair P, Mishra SR, Ramsis M, Spaulding EM, Brewer LC, Forman DE, Golbus JR, Martin SS, Nallamothu BK, Beatty AL.   +15 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Human-Centered Multimedia [PDF]

, 2009
openaire   +2 more sources

Human-centered design of an artificial intelligence monitoring system: the Vanderbilt Algorithmovigilance Monitoring and Operations System. [PDF]

JAMIA Open
Salwei ME, Davis SE, Reale C, Novak LL, Walsh CG, Beebe R, Nelson S, Sundrani S, Rose S, Wright A, Ripperger M, Shave P, Embí P.   +12 more
europepmc   +1 more source