Results 211 to 220 of about 455,243 (269)

Design and Development of an Intervention to Improve the Quality and Safety of Pediatric Dental Sedation: A Human-Centered Design Approach. [PDF]

J Patient Saf
Zouaidi K, Yeager J, Bangar S, Tungare S, Mehta U, Urata J, Yansane AI, Tanbonliong T, Kim J, Sedlock E, Kookal KK, Xiao Y, Oluwabunmi T, Spallek H, Franklin A, Olson GW, White J, Kalenderian E, Walji MF.   +18 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Toward Human-Centered Artificial Intelligence for Users' Digital Well-Being: Systematic Review, Synthesis, and Future Directions.

JMIR Hum Factors
Shin Y.
europepmc   +1 more source

Human-Centered Design and Development in Digital Health: Approaches, Challenges, and Emerging Trends. [PDF]

Cureus
Tzimourta KD.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Adolescents as co-designers: adapting human-centered design to develop school-based mental health strategies in northern Ghana. [PDF]

BMC Public Health
Leung CL, Goka PK, Atangongo B, Bingle MMM, Adu I, Atchulo AR, Boateng L, Huang KY, Laiteerapong N, Limann G, Volerman A, Amadu PM, Koomson WFH.   +12 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Human-centered design and maternity care: is this a possible interplay?-a systematic review. [PDF]

BMC Pregnancy Childbirth
Landeiro F, Silva M, Moura CVE, Martins C, Miller P, Ferraz S, de Azevedo AP, Gancho S, Rocha L, Patrício R, Nunes I.   +10 more
europepmc   +1 more source