Results 111 to 120 of about 3,890 (282)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

When warehouses dream:a systems-informed exploration of Industry 5.0 principles in warehousing performance management [PDF]

This study aims to help logistics managers design a comprehensive performance management methodology for Warehousing 5.0. It identifies essential key performance indicators for warehouses in the era of Industry 5.0 (KPIs-5.0), drawing from traditional ...
Alaya, Amer, Demir, Gulay, Mohammed, Ahmed, Rahman, Maryam, Shah, Bhavin   +4 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perceptions of Industry 5.0: Sustainability Perspective

BioResources
Today, Industry 5.0 can be regarded as the latest stage of industrial revolution, where collaboration between humans and smart technologies reaches a new level. This editorial presents insights into Industry 5.0.
J. Paulo Davim
doaj  

Exotopy: Mikhail Bakhtin and Jacques Lacan on the Outside Context of Discourse [PDF]

Slavica TerGestina, 2018
The present text treats the concept of exotopy in Bakhtin and Lacan, explicating the direction and the possible indices for comparison between post-Marxism and Psychoanalysis.
Kalinova, Maria
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

On the Issue of Defining the Concept of a Digital Platform in the Field of Taxation: The Legal Aspect

Теоретическая и прикладная юриспруденция
Introduction. In the context of the creation and development of digital platforms, the relevance of the problem of defining their concepts and adequately regulating the norms of the tax legislation of the Russian Federation is indisputable, and is due to
O. I. Lyutova
doaj  

Automation and Robotics Pilot Lines in the Context of Industry 5.0

Applied Sciences
Pilot lines have become a key element in modern industry. The demands for resilience, human-centricity, and sustainability in Industry 5.0, combined with technological innovations, highlight the critical role of these lines in the new industrial paradigm.
Rubén Alonso, Tomás F. Sánchez, Diego A. Alfaro, Yarens J. Cruz, Alberto Villalonga, Fernando Castaño   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source