Results 41 to 50 of about 619,653 (297)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hazards Associated with Human Machine Interface in Part 121 Operations Based on ASRS Reports

International Journal of Aviation, Aeronautics, and Aerospace, 2019
Hazard identification is the first step of safety risk management within a safety management system. Hazards of human-machine interaction could exist within Part 121 operations, of which the operator is unaware.
Brian T Musselman
doaj   +1 more source

Principles of procedural support in man-machine systems [PDF]

, 1990
Two alternative ways of embedding human performance models into man-machine systems exist, namely embedding them directly into the man-machine interface or into the technical system proper as a decision support.
Hollnagel, E., Weir, G.R.S.
core  

GUIDER: a GUI for semiautomatic, physiologically driven EEG feature selection for a rehabilitation BCI [PDF]

, 2017
GUIDER is a graphical user interface developed in MATLAB software environment to identify electroencephalography (EEG)-based brain computer interface (BCI) control features for a rehabilitation application (i.e. post-stroke motor imagery training).
Cincotti, Febo, Colamarino, Emma, Martinoia, M., Mattia, D., Pichiorri, Floriana, Schettini, Francesca   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PrintAssist—a conversational human-machine interface for 3D printers

i-com, 2023
3D printers are no longer found only in industry, universities or makerspaces but now are increasingly used in domestic settings. Personal fabrication will increase in the coming years, and 3D printing will play an important role in this process.
Jasche Florian, Weber Philip, Liu Shi, Ludwig Thomas   +3 more
doaj   +1 more source

Vision of a Visipedia [PDF]

, 2010
The web is not perfect: while text is easily searched and organized, pictures (the vast majority of the bits that one can find online) are not. In order to see how one could improve the web and make pictures first-class citizens of the web, I explore
Perona, Pietro
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source