Results 151 to 160 of about 4,369,058 (316)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A benchmark case for aeroacoustic simulations involving fluid-structure-acoustic interaction transferred from the process of human phonation

Acta Acustica
Modeling fluid-structure-acoustic interaction is a highly challenging task and currently there is a lack of available benchmark datasets. For instance, to understand the processes of human phonation, it is essential to fully understand the fluid ...
Schoder Stefan, Falk Sebastian, Wurzinger Andreas, Lodermeyer Alexander, Becker Stefan, Kniesburges Stefan   +5 more
doaj   +1 more source

Modeling Human-Structure Interaction Using a Controller System

, 2020
The effects of human loads on structures are difficult to predict because they depend on the type of activity people are performing. However, models for typical activities such as standing, sitting and jumping have been proposed in the literature. Traditional models represent the human body as a system of lumped masses, dampers and springs arranged in ...
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An Aspect of Dynamic Human-structure Interaction

, 2008
It is known that humans and structures interact. Humans can cause structures to vibrate, and excessive vibrations may occur if the motion frequency of humans coincides with a resonant frequency of the structural system. It is also known that stationary humans (such as humans sitting or standing on the structure) influence the dynamic behaviour and ...
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Timing of human rhythmic jumping with vertical floor vibrations tends towards mechanically efficient solutions

Scientific Reports
Jumping on vibrating platforms is described not only by the frequency of jumping (FoJ) but also by the timing of key events in a cycle of jumping relative to vibrations. This study aimed to capture timing and efficiency-related adaptations during jumping
Nimmy Mariam Abraham, Stana Zivanovic, Genevieve Williams   +2 more
doaj   +1 more source

Modeling Human-Robot Interaction Based on Generic Interaction Patterns

, 2010
Peltason J, Wrede B. Modeling Human-Robot Interaction Based on Generic Interaction Patterns. In: AAAI Fall Symposium: Dialog with Robots. Arlington, VA, USA: AAAI Press; 2010.While human-robot interaction is typically limited to restrictive command ...
Peltason, Julia, Wrede, Britta ; https://orcid.org/   +1 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source