Results 181 to 190 of about 1,249,402 (218)

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Synthetic resonance: a framework for growth-oriented human-AI relationships. [PDF]

Front Artif Intell
Fabes RA.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Rethinking Giftedness in the Age of Generative AI: A Relational Epistemic Agency Model for Advanced Learners. [PDF]

J Intell
Umar ÇN.
europepmc   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases. [PDF]

Neurol Sci
Miccoli L, Fullone R, Delli Pizzi S, Tomaiuolo F, Sensi SL, Floresta G, Granzotto A.   +6 more
europepmc   +1 more source

Corpus-level behavioral intensity in human-AI conversations. [PDF]

Front Artif Intell
Mera-Navarrete A, Revelo S, Beltrán-Morales J, Villegas-Ch W.   +3 more
europepmc   +1 more source

Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures. [PDF]

Genome Biol
Tamandeh E, Kunwar K, Bigge J, Serohijos A, Schumacher J, Maj C, Dasmeh P.   +6 more
europepmc   +1 more source