Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
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Office of the Vice President for Human Resources
core
Cynomolgus Monkey (Macaca fascicularis) Embryo Models: From Developmental Benchmarks to Functionally Testable Embryoids. [PDF]
Jeong Y, Byun J, Moon SH, Kwon T.
europepmc +1 more source
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Construct Validity of Frontier Large Language Models on 4 Spanish Health Professions Specialty-Access Examinations (MIR, EIR, PIR, and FIR): Cross-Sectional Benchmarking and Psychometric Study. [PDF]
García-Hidalgo C +5 more
europepmc +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
HUMAN Deliverable D4.8 – requirements for the cognitive model after cycle 2
HUMAN Model-based Analysis of Human Errors during Aircraft Cockpit System Design.Technical Report HUMAN Project, proj. number 211988, HUMAN/WP4/TNO/D4.
Osterloh, J.P. +3 more
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A human erythropoietin-albumin fusion protein tailored for enhanced plasma half-life and delivery across mucosal surfaces. [PDF]
Anthi AK +9 more
europepmc +1 more source
Histograms of oriented gradients for human detection
Navneet Dalal, B. Triggs
semanticscholar +1 more source

