Results 51 to 60 of about 23,986,359 (358)

Substance abuse treatment in Nigeria: applying a biopsychosocial-spiritual framework at MACCARCA

Frontiers in Psychology
IntroductionSubstance use disorders are a growing public-health problem in Nigeria where many existing treatments are fragmented and heavily influenced by spiritual/traditional approaches.
Mary Frances Ezeakunne, Mary Frances Ezeakunne, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer   +5 more
doaj   +1 more source

Huldeblyk aan ’n blymoedige gewer

Literator, 2017
No abstract available.
Thys Human
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The radical rationalization of management thought: Its causes and consequences

South African Journal of Business Management, 1986
Radical rationalization refers to the phenomenon where means are seen as ends-in-themselves. Translated to the practice of management this would mean that the exercise of techniques is absolutized to the extent that ends (goals) are lost from sight.
P. Human
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Perception Is Reality: How Employees Perceive What Motivates HR Practices Affects their Engagement, Behavior and Performance [PDF]

, 2011
KEY FINDINGS Espoused or intended HR practices have differential effects on employee engagement and citizenship behaviors depending on the underlying management motives employees attribute to those practices. To achieve desired organizational outcomes,
Center for Advanced Human Resource Studies
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Biochemical insight into the prion protein family

Frontiers in Cell and Developmental Biology, 2015
Prion protein family comprises proteins, which share not only similarity in their primary structure, but also similarity in their fold. These two groups of similarity presume a parceling in their respective biological function through the common ...
Human eRezaei
doaj   +1 more source

Human Rights, Human Needs, Human Development, Human Security: elations ships between Four International ‘Human’ Discourses

Forum for Development Studies, 2007
Human rights, human development and human security form increasinglyimportant, partly interconnected, partly competitive and misunderstood ethicaland policy discourses. Each tries to humanize a pre-existing and unavoidablemajor discourse of everyday life, policy and politics; each has emerged withinthe United Nations world; each relies implicitly on a ...
openaire   +2 more sources