Results 121 to 130 of about 14,968,121 (261)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

HASC2011corpus: Towards the Common Ground of Human Activity Recognition [PDF]

Human activity recognition through the wearable sensor will enable a next-generation human-oriented biquitous computing. However, most of research on human activity recognition so far is based on small number of subjects, and non-public data. To overcome
Iwasaki, Yohei, Kaji, Katsuhiko, 17300, 17301, Sumi, Yasuyuki, 17302, 井上, 創造, 27425, Kawaguchi, Nobuo, Inoue, Sozo, イノウエ, ソウゾウ, Ogawa, Nobuhiro, 17307, Yang, Tianhui, 17303, 17305, 17306, 17299, Terada, Tsutomu, 17296, Yang, Ying, 17297, 17298, Kawahara, Yoshihiro, Nishio, Nobuhiko, 140, Murao, Kazuya, 90346825, 9335840200   +28 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A system of human vital signs monitoring and activity recognition based on body sensor network

, 2014
Purpose - The purpose of this paper is to develop a health monitoring system that can measure human vital signs and recognize human activity based on body sensor network (BSN).
Wang ZL(王哲龙), Zhao, Cong, Qiu, Sen
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

BodyFlow: An Open-Source Library for Multimodal Human Activity Recognition

Sensors
Human activity recognition is a critical task for various applications across healthcare, sports, security, gaming, and other fields. This paper presents BodyFlow, a comprehensive library that seamlessly integrates human pose estimation and multiple ...
Rafael del-Hoyo-Alonso, Ana Caren Hernández-Ruiz, Carlos Marañes-Nueno, Irene López-Bosque, Rocío Aznar-Gimeno, Pilar Salvo-Ibañez, Pablo Pérez-Lázaro, David Abadía-Gallego, María de la Vega Rodrigálvarez-Chamarro   +8 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Reasoning-Enhanced Few-Shot Human Activity Recognition via Visual Reinforcement Learning

IEEE Access
Most existing human activity recognition (HAR) models rely on large-scale labeled datasets for training, which makes it difficult for HAR models to recognize activity classes unseen during training when only a few samples are available.
Wenqi Zheng, Yutaka Arakawa
doaj   +1 more source