Results 141 to 150 of about 14,335,879 (294)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

BodyFlow: An Open-Source Library for Multimodal Human Activity Recognition

Sensors
Human activity recognition is a critical task for various applications across healthcare, sports, security, gaming, and other fields. This paper presents BodyFlow, a comprehensive library that seamlessly integrates human pose estimation and multiple ...
Rafael del-Hoyo-Alonso, Ana Caren Hernández-Ruiz, Carlos Marañes-Nueno, Irene López-Bosque, Rocío Aznar-Gimeno, Pilar Salvo-Ibañez, Pablo Pérez-Lázaro, David Abadía-Gallego, María de la Vega Rodrigálvarez-Chamarro   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A Lightweight Human Activity Recognition Method for Ultra-wideband Radar Based on Spatiotemporal Features of Point Clouds

Leida xuebao
Low-frequency Ultra-WideBand (UWB) radar offers significant advantages in the field of human activity recognition owing to its excellent penetration and resolution.
Yongkun SONG, Tianxing YAN, Ke ZHANG, Xian LIU, Yongpeng DAI, Tian JIN   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reasoning-Enhanced Few-Shot Human Activity Recognition via Visual Reinforcement Learning

IEEE Access
Most existing human activity recognition (HAR) models rely on large-scale labeled datasets for training, which makes it difficult for HAR models to recognize activity classes unseen during training when only a few samples are available.
Wenqi Zheng, Yutaka Arakawa
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Vision-based manipulative gesture recognition in a human-robot interaction scenario [PDF]

, 2008
Li Z. Vision-based manipulative gesture recognition in a human-robot interaction scenario. Bielefeld (Germany): Bielefeld University; 2008.Nowadays, many people are expecting an age of personal robots just as what happened in the evolution of computers ...
Li, Zhe
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