Results 81 to 90 of about 955,582 (345)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Association between osteosarcopenic obesity and hypertension among four minority populations in China: a cross-sectional study

open access: yesBMJ Open, 2019
Objective Osteosarcopenic obesity (OSO) may be associated with an increased prevalence of hypertension. The aim of this study was to examine the difference in the prevalence of OSO and hypertension among four minority populations in China and explore the
Peng Liu   +9 more
doaj   +1 more source

Reshaping the teaching of anatomy: tensions affecting the introductory undergraduate course [PDF]

open access: yes, 2011
Este artigo pretende iniciar a discussão da condição curricular da Anatomia Humana nos cursos médicos da atualidade frente a tensões que incidem sobre ela, que a podem estar levando a uma crise de manutenção de seu status sociocurricular.
ALMEIDA, Maria Isabel de   +1 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Exploring the Neuroprotective Potentials of Flavonoid Metabolites in Syzygium aromaticum: A Review with in-silico Insight to Therapeutic Potential

open access: yesJournal of Experimental Pharmacology
Ekom Monday Etukudo,1 Ibe Michael Usman,1 Augustine Oviosun,1 Vivian Onyinye Ojiakor,1 Wusa Makena,1 Elna Owembabazi,1 Patrick Maduabuchi Aja,2 Bives Mutume Nzanzu Vivalya,3 Victor Bassey Archibong,4 Emeka Anyanwu1 1Human Anatomy Department, Kampala ...
Etukudo EM   +9 more
doaj  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

POU3F4 up-regulates Gli1 expression and promotes neuronal differentiation and synaptic development of hippocampal neural stem cells

open access: yesStem Cell Research & Therapy
Background Neural stem cells (NSCs) are considered to be the most promising cell type for cell replacement therapy in neurodegenerative diseases. However, their low neuronal differentiation ratio impedes their application in such conditions.
Lei Zhang   +15 more
doaj   +1 more source

Immolation of the Phoenix

open access: yes, 2017
The time period of wunderkammer opened a plethora of sciences that scholars devoted their lives to. Among these were botany, zoology, ethnography – studies that had already been somewhat established before.
Raphaelson, James H.
core  

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