Results 101 to 110 of about 6,769,675 (300)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The cerebellum is involved in implicit motor sequence learning
Frontiers in NeuroscienceBackgroundImplicit motor sequence learning (IMSL) is a cognitive function that allows us to execute multiple movements in a specific sequential order and plays a crucial role in our daily functional activities.
Mahyar Firouzi +17 more
doaj +1 more source
The role of boron for human body
One Health & Risk Management, 2022 Introduction. Boron is a little known trace element from the metalloids class that is supposed to be essential for the human body. The main source of boron for humans is drinking water.
Maria-Victoria RACU
doaj
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Introduction to the Human Body With A Krama Inggil Language-Based Microcontroller ATmega 16 [PDF]
, 2012 The introduction of human limbs with language-based Krama Inggil ATmega microcontroller 16 is a tool that serves to introduce the members of the human body in one language Krama Inggil based microcontroller ATmega 16. This tool is made for the purpose
Desi, Ariyati
core
Scientific ReportsEvaluation of the intestinal absorption and hepatic metabolism is crucial to the development of orally administered drugs. Previous evaluation systems have assessed intestinal epithelial cells and hepatocytes separately. To develop an experimental system
Ryosuke Negoro +4 more
doaj +1 more source
Franciscanum, 2017 Drama of women with HIV is called to become a theological place because God speaks through the words and deeds that occur in that place and because its liberating and saving potential for the individuals involved.
José Luis Meza Rueda
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source