Results 151 to 160 of about 14,485,412 (367)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Students’ conceptions about energy and the human body [PDF]
Science Education International, 2010 Students’ understanding of energy has been primarily within the domain ofphysics. This study sought to examine students’ understanding of conceptsrelating to energy and the human body using pencil and paperquestionnaires administered to 610 students in ...
David F Treagust, Michael Mann
doaj
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Over or Under? Mental Representations and the Paradox of Body Size Estimation
Frontiers in Psychology, 2021 Kevin R. Brooks +5 more
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Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Advancing intestinal disease research using gut-on-a-chip
Regenerative TherapyThe intestine is exposed constantly to mechanical stimuli, including blood flow or peristalsis. Recently, gut-on-a-chip models have been developed to recapitulate these physiological stresses.
Fuki Yokoi +2 more
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ON RAILROAD INJURIES OF THE EXTREMITIES OF THE HUMAN BODY, WITH OBSERVATIONS ON THE SITE OF AMPUTATION, AND SUBSEQUENT TREATMENT OF THE STUMP. [PDF]
, 1884 Theodore R. Varick
openalex +1 more source
ReligionsWe discuss the concept of a ‘body’, the individual body as the lived experience of the body, the social body, shaped by the tensions between the demands of a social/moral order and the egocentric drives, and the body politic, as an institutionalized and disciplined body.
Ursula Plöckinger, Ulrike Ernst-Auga
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Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source