Results 71 to 80 of about 2,587,341 (268)

Single Nucleotide Polymorphisms within Calcineurin-Encoding Genes are Associated with Response to Aerobic Training in Han Chinese Males

Annals of Applied Sport Science, 2016
Calcineurin, which functions in calcium signaling, is expressed in skeletal and cardiac muscle and has been linked to sensitivity to muscle strength training. It is also proposed to contribute to individual aerobic endurance.
Rong-mei Xu, Tao Lu, Lingxian Yan, Qinghua Song   +3 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dual inhibition of intercellular adhesion molecule-1 and nucleolin reduces RSV infection efficiency in human respiratory organoids

Molecular Therapy: Nucleic Acids
Respiratory syncytial virus (RSV) is one of the major causes of lower respiratory tract infections, particularly in infants and older adults. However, the host factors mediating infection remain poorly defined.
Abeer Keshta, Rina Hashimoto, Yuki Kitai, Yoshitaka Nakata, Ayaka Sakamoto, Shimpei Gotoh, Makoto Takeda, Kazuo Takayama   +7 more
doaj   +1 more source

The Reflection on the Originality of the Study of Physical Education, Health and Sport Sciences in Japan [PDF]

The Asian Journal of Kinesiology
OBJECTIVES The purpose of this study is to discuss the redefinition of the Physical Education, Health, and Sport Sciences (PEHSS) in Japan by considering its originality. METHODS The method of this study is reflective consideration in philosophy.
Koji Takahashi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Toward a unified vocabulary for embodiment research challenges and solutions

npj Science of Learning
Embodiment research spans psychology, neuroscience, education, artificial intelligence, and public health, yet overlapping labels and shifting meanings slow cumulative progress.
Peng Wang, Jingming Li, Qian Yu, Liye Zou, Xia Xu, Myrto Mavilidi, Ryan S. Falck, Fabian Herold, Robert J. Schinke, Markus Raab, Fred Paas   +10 more
doaj   +1 more source

The cerebellum is involved in implicit motor sequence learning

Frontiers in Neuroscience
BackgroundImplicit motor sequence learning (IMSL) is a cognitive function that allows us to execute multiple movements in a specific sequential order and plays a crucial role in our daily functional activities.
Mahyar Firouzi, Mahyar Firouzi, Mahyar Firouzi, Mahyar Firouzi, Kris Baetens, Kris Baetens, Catalina Duta, Catalina Duta, Chris Baeken, Chris Baeken, Chris Baeken, Frank Van Overwalle, Frank Van Overwalle, Eva Swinnen, Eva Swinnen, Eva Swinnen, Natacha Deroost, Natacha Deroost   +17 more
doaj   +1 more source

The role of boron for human body

One Health & Risk Management, 2022
Introduction. Boron is a little known trace element from the metalloids class that is supposed to be essential for the human body. The main source of boron for humans is drinking water.
Maria-Victoria RACU
doaj