Results 191 to 200 of about 1,330,803 (255)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Lost in Sleep Transition: Tangled Sleep and Thermoregulation in Dravet Syndrome. [PDF]

Epilepsy Curr
Wong JC.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Electromagnetic and Electrophysiological Modeling of Cardiac Stimulation Thresholds in 13 MRI Gradient Systems and 56 Body Models. [PDF]

Magn Reson Med
Klein V, Davids M, Ferris NG, Edmonson J, Gebhardt M, Rattenbacher D, van den Brink JS, Steckner M, Wald LL, Guérin B.   +9 more
europepmc   +1 more source

PFAS Toxicity: What's True, What's Not, and What Really Matters. [PDF]

Environ Sci Technol
DeWitt JC, Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Trier X, Wang Z.   +9 more
europepmc   +1 more source

From expert opinion to data driven selection of sports equipment: Boot selection in alpine ski racers. [PDF]

PLoS One
Kranzinger C, Stöggl T, Holzer H, Kröll J, Lasshofer M.   +4 more
europepmc   +1 more source