Results 51 to 60 of about 575,122 (306)

Engineering Human Bone Marrow Proxies [PDF]

Cell Stem Cell, 2018
Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics. Here, we discuss challenges in generating relevant human bone marrow proxies, potential design principles, and future directions.
Paul E, Bourgine, Ivan, Martin, Timm, Schroeder   +2 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Bilateral glomus tympanicum tumors: human temporalbone study

Clinics and Practice, 2018
To describe human temporal bones with bilateral glomus tympanicum tumors. Patient is 83-year-old black female who no pulsatile tinnitus. The histopathologic characteristics of human temporal bones after death were setting Department of Otolaryngology of ...
Hisaki Fukushiama, Hirotaka Hara, Michael M. Paparella, Mohamed F. Oktay, Patricia A. Schachern, Sebahattin Cureoglu   +5 more
doaj   +1 more source

Validation of a 3D-printed human temporal bone model for otology surgical skill training

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2021
Hypothesis: Three-dimensional (3D) printed temporal bones are comparable to cadaveric temporal bones as a training tool for otologic surgery. Background: Cadaveric temporal bone dissection is an integral part of otology surgical training.
Wade W. Chien, Melville J. da Cruz, Howard W. Francis   +2 more
doaj   +1 more source

Predictive Modelling of Bone Age through Classification and Regression of Bone Shapes [PDF]

, 2014
Bone age assessment is a task performed daily in hospitals worldwide. This involves a clinician estimating the age of a patient from a radiograph of the non-dominant hand.
Bagnall, Anthony, Davis, Luke
core   +1 more source

The hand of Homo naledi [PDF]

, 2015
A nearly complete right hand of an adult hominin was recovered from the Rising Star cave system, South Africa. Based on associated hominin material, the bones of this hand are attributed to Homo naledi.
AB Falsetti, AS Deane, AS Deane, AS Deane, BG Richmond, C Rolian, C Rolian, CM Orr, CO Lovejoy, CV Ward, CV Ward, CV Ward, CV Ward, CV Ward, D Lordkipanidze, DE Lieberman, DJ Green, DM Alba, F Weidenreich, H Preuschoft, HM McHenry, JE Mosimann, JR Napier, JR Napier, JT Stern Jr., KD Hunt, LR Berger, LR Berger, ME Bush, MM Shrewsbury, MW Markze, MW Marzke, MW Marzke, MW Marzke, MW Marzke, MW Marzke, MW Tocheri, MW Tocheri, MW Tocheri, MW Tocheri, MW Tocheri, NH Nguyen, RH Tuttle, RL Susman, S Almécija, SL Smith, TL Kivell, WEH Harcourt-Smith, WL Jungers, WL Jungers   +49 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The bone battle: The attack on scientific freedom [PDF]

, 2009
NAGPRA (lovely acronym) is a federal law, passed in 1989, that requires agencies receiving federal support to allow federally recognized tribes to obtain “culturally affiliated” Native American human remains and artifacts - in other words, to reclaim ...
Weiss, Elizabeth
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Identification of Victims Who Have Experienced Advanced Decay

Scripta Score Scientific Medical Journal, 2022
Background. In the process of investigating a criminal offense, knowing the identity of the victim is something that has a very important meaning, namely as an initial step of the investigation that must be made clear before the next steps can be taken ...
Asan Petrus Sembiring
doaj   +1 more source