Results 81 to 90 of about 575,122 (306)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Modern issues of surgical anatomy of the ligamentary apparatus and metatarsal bones of the human foot

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
The article presents an analysis of scientific literature devoted to the study of surgical anatomy of the ligamentous apparatus and metatarsal bones of the human foot.
D. V. Dukov, A. N. Russkikh, A. D. Shabokha, F. V. Alyab'ev, A. F. Makarov   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ultrasonic properties of human bones in senile osteoporosis

Acta Orthopaedica et Traumatologica Turcica, 2021
Biomechanical properties of the femoral heads of six cases with osteoporosis who underwent hip surgery were investigated by ultrasonic methods. Ultrasonic velocities and moduli of elasticity in the tangential, radial and axial directions were determined ...
Yener Nail Yeni, Ugur Gunel, Feza Korkusuz, Nuri Akkas   +3 more
doaj  

Radiocarbon dates from the Oxford AMS system: archaeometry datelist 35 [PDF]

, 2014
This is the 35th list of AMS radiocarbon determinations measured at the Oxford Radiocarbon Accelerator Unit (ORAU). Amongst some of the sites included here are the latest series of determinations from the key sites of Abydos, El Mirón, Ban Chiang, Grotte
Baker, D., Brock, F., Bronk Ramsey, C., Ditchfield, P., Higham, T. F. G., Staff, R. A.   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sex and side determination of human hip bone by metric parameters of its posterior border

National Journal of Clinical Anatomy, 2013
Background: Identification of sex from skeletal remains is of medico-legal and anthropological importance for forensic experts, anthropologists and anatomists.
Sarita R Margam, Megha A Doshi, Surekha D Jadhav, Raosaheb J Patil, Manoj P Ambali   +4 more
doaj   +1 more source

Evidences of Interaction Homo-Cuon in three Upper Pleistocene Sites of the Iberian Mediterranean Central Region [PDF]

, 2013
Several cuon bones were discovered recently in three Upper Pleistocene archeological sites in the central area of the Iberian Mediterranean. This has proved that there were different types of interactions between dholes and prehistoric human groups ...
Aura Tortosa, J. Emili, Morales Pérez, Juan Vicente, Pérez Ripoll, Manuel, Real Margalef, Cristina, Sanchis Serra, Alfred, Villaverde Bonilla, Valentín   +5 more
core   +1 more source

PCR diagnostics of Mycobacterium tuberculosis in historic human long bone remains from 18th century burials in Kaiserebersdorf, Austria [PDF]

, 2008
Background In the present pilot study we applied recently published protocols for detecting Mycobacterium tuberculosis in human remains.
Bachmann, Lutz, Däubl, Barbara, Lindqvist, Charlotte, Kruckenhauser, Luise, Teschler-Nicola, Maria, Haring, Elisabeth   +5 more
core   +1 more source