Results 101 to 110 of about 801,707 (316)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models [PDF]

, 2014
Yasuhiro Funahashi, Kiyoshi Okamoto, Yusuke Adachi, Taro Semba, Mai Uesugi, Yoichi Ozawa, Osamu Tohyama, Taisuke Uehara, Takayuki Kimura, Hideki Watanabe, Makoto Asano, Satoshi Kawano, Xavier Tizon, Paul J. McCracken, Junji Matsui, Ken Aoshima, K. Nomoto, Yoshiya Oda   +17 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer [PDF]

, 2010
Lyndsay V. Rhodes, Sarah P. Short, Nicole F. Neel, Virgilio A. Salvo, Yun Zhu, S. R. Elliott, Yongkun Wei, Dihua Yu, Menghong Sun, Shannon E. Muir, Juan P. Fonseca, Melyssa R. Bratton, Chris Segar, Syreeta L. Tilghman, Tammy Sobolik-Delmaire, Linda W. Horton, Snjezana Zaja‐Milatovic, Bridgette M. Collins‐Burow, Scott Wadsworth, Barbara S. Beckman, Charles E. Wood, Suzanne A.W. Fuqua, Kenneth P. Nephew, Paul Dent, Rebecca A. Worthylake, Tyler J. Curiel, Mien‐Chie Hung, Ann Richmond, Matthew E. Burow   +28 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Enhancing translational research in metastatic cancer through an open science environment: the UPTIDER experience

npj Precision Oncology
Translational research in metastatic cancer is limited by insufficient metastatic samples. Post-mortem tissue donation programs address this issue by facilitating comprehensive sample collection.
Anirudh Pabba, Marion Maetens, Amena Mahdami, Tatjana Geukens, Maxim De Schepper, Gitte Zels, Karen Van Baelen, Sophia Leduc, Ha Linh Nguyen, Josephine Van Cauwenberge, Kristien Borremans, Sigrid Hatse, Madita Nysen, Emma Rousseau, Angelica Di Tommaso, Bram Boeckx, Patrick Neven, Hans Wildiers, Elia Biganzoli, Peter Vermeulen, Wouter Van Den Bogaert, Diether Lambrechts, Giuseppe Floris, Christine Desmedt, François Richard   +24 more
doaj   +1 more source

5α-Reductases in Human Breast Carcinoma: Possible Modulator ofin SituAndrogenic Actions¹ [PDF]

, 2001
Takashi Suzuki, Andrew D. Darnel, Jun‐ichi Akahira, Naohiro Ariga, Sayaka Ogawa, Chika Kaneko, Junji Takeyama, Takuya Moriya, Hironobu Sasano   +8 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source