Results 161 to 170 of about 9,471,907 (311)

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

open access: yesAdvanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu   +12 more
wiley   +1 more source

Human Capital, Schooling and Health Returns [PDF]

open access: yes
A consensus has been forged in the last decade that recent periods of sustained growth in total factor productivity and reduced poverty are closely associated with improvements in a population's child nutrition, adult health, and schooling, particularly ...
T. Paul Schultz
core  

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

open access: yesAdvanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen   +5 more
wiley   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

open access: yesAdvanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico   +7 more
wiley   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

open access: yesAdvanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin   +7 more
wiley   +1 more source

Accumulation of Human Capital and FDI Inflows in ASEAN-3 Countries (Malaysia, Thailand, Indonesia) [PDF]

open access: yes
The event of globalization and the increasing inflows of FDI to developing countries create a potential for technology transfers and spillovers which suggest a potential for future growth of human capital, and output.
Heirsh SOLTANPANAH   +1 more
core  

Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

open access: yesAdvanced Science, EarlyView.
Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li   +11 more
wiley   +1 more source

Human Capital Impact on the Cities Development

open access: yes
Human capital is important for the country's socio-economic factor in the development of competitive increases. Concentration in certain areas of human capital reduces the transfer of knowledge and new knowledge and ideas of creation and thus increases ...
Kamola, Līga, Nešpors, Viktors
core  

Human Capital and Regional Wage Gaps. [PDF]

open access: yes
This paper uses micro-level data to analyse the effect of human capital on regional wage differentials. The results for the set of Spanish regions confirm that they differ in the endowment of human capital, but also that the return that individuals ...
Elisabet Motellón, Enrique López-Bazo
core  

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