Results 91 to 100 of about 9,965,276 (342)

Prevalence of obesity, type II diabetes mellitus, hyperlipidemia, and hypertension in the United States: findings from the GE Centricity Electronic Medical Record database. [PDF]

, 2010
This study analyzed GE Centricity Electronic Medical Record (EMR) data to examine the effects of body mass index (BMI) and obesity, key risk factor components of metabolic syndrome, on the prevalence of 3 chronic diseases: type II diabetes mellitus ...
Albert G. Crawford, Candace Gunnarsson, Christine Cote, Joseph Couto, Kannel WB, Kara Haas, Mehmet Daskiran, Rob Schuette, Sara Haas, Somesh C. Nigam   +9 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Human-centric manufacturing culture: a research study of MedTech manufacturers in Ireland

Production and Manufacturing Research: An Open Access Journal
Digital manufacturing is rapidly evolving; however, this transformation is predominantly technology centric. Human-centric manufacturing shifts the paradigm for the digital manufacturing enterprise towards a human focus to realising its envisioned ...
Donna H. Rhodes, Sara Cuddy, Malcolm Jeffers, Fiona O’Rourke   +3 more
doaj   +1 more source

Adaptive development and maintenance of user-centric software systems [PDF]

, 2004
A software system cannot be developed without considering the various facets of its environment. Stakeholders – including the users that play a central role – have their needs, expectations, and perceptions of a system.
Alspaugh, Beynon-Davies, Borgholm, Breitman, Bødker, Claus Pahl, Crnkovic, Dix, Egyed, Grønbæk, Kazman, Kotonya, Kösters, Lee, Lung, Medvidovic, Moisiadis, Nuseibeh, Pahl, Russo, Shaw, Smeaton, Smeaton, Sommerville, Sutcliffe   +24 more
core   +1 more source

Towards Human-Centric Manufacturing: Exploring the Role of Human Digital Twins in Industry 5.0

Sustainability
Human-centricity, a cornerstone of Industry 5.0, emphasizes the central role of human needs and capabilities in the technological landscape of modern manufacturing.
Ilaria Bucci, Virginia Fani, Romeo Bandinelli   +2 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Motivational and Activity-Based Programs for Training and Professional Development of Specialists in Management, Development and Transformation Support

Высшее образование в России
Advanced companies face urgent challenges to ensure strategic sustainability and innovative development in an environment of uncertainty and increasing complexity.
P. D. Rabinovitch, K. E. Zavedenskiy, L. V. Kremneva, S. N. Apenko   +3 more
doaj   +1 more source

Lean in universities: assessing practicality across university functions [PDF]

Proceedings of the Estonian Academy of Sciences
The lean management approach supports the ambitions of the European Union Industry 5.0 doctrine in human-centricity, adequate use of technology, and sustainability.
Kadri Kristjuhan-Ling, Kashif Mahmood
doaj   +1 more source

Global Health Law: A Definition and Grand Challenges [PDF]

, 2008
It has been only recently that scholars have engaged in a serious discussion of public health law. This academic discourse examines the role of the state and civil society in health promotion and disease prevention within the country.
Gostin, Lawrence O., Taylor, Allyn L.
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source