Results 101 to 110 of about 9,965,276 (342)

Showcasing a digital twin for higher educational buildings: developing the concept toward human centricity

Frontiers in Built Environment
Digital twin technology is an emerging technology within the built environment. Yet, there are many unexplored opportunities to utilize digital twins for facilitating the transformation toward a climate-neutral building stock while also meeting the ...
Katarina Bäcklund, Per Lundqvist, Marco Molinari   +2 more
doaj   +1 more source

Computational role of eccentricity dependent cortical magnification [PDF]

, 2014
We develop a sampling extension of M-theory focused on invariance to scale and translation. Quite surprisingly, the theory predicts an architecture of early vision with increasing receptive field sizes and a high resolution fovea -- in agreement with ...
Isik, Leyla, Mutch, Jim, Poggio, Tomaso
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Li-Fi based on security cloud framework for future IT environment

Human-Centric Computing and Information Sciences, 2018
In the new era of the Internet of Things (IoT), all information related to the environment, things and humans is connected to networks. Humans, too, can be considered an integral part of the IoT ecosystem. The growing human-centricity of IoT applications
P. Sharma, Jung Hyun Ryu, Kyung Yeob Park, Jin Ho Park, Jong Hyuk Park   +4 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Fog-enabled Edge Learning for Cognitive Content-Centric Networking in 5G

, 2018
By caching content at network edges close to the users, the content-centric networking (CCN) has been considered to enforce efficient content retrieval and distribution in the fifth generation (5G) networks.
Li, Gaolei, Li, Jianhua, Wu, Jun
core  

Damping of glacial-interglacial cycles from anthropogenic forcing

, 2014
Climate variability over the past million years shows a strong glacial-interglacial cycle of ~100,000 years as a combined result of Milankovitch orbital forcing and climatic resonance.
Haqq-Misra, Jacob
core   +1 more source

Comorbidities Associated with Large Abdominal Aortic Aneurysms [PDF]

, 2019
BACKGROUND: Abdominal aortic aneurysm has become increasingly important owing to demographic changes. Some other diseases, for example, cholecystolithiasis, chronic obstructive pulmonary disease, and hernias, seem to co-occur with abdominal aortic ...
Althoff, Christian E., Greiner, Andreas, Hinterseher, Irene, Kuivaniemi, Helena, Miszczuk, Milena, Müller, Verena, Stroux, Andrea   +6 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Law, Technology, and Our Governance Dilemma

Laws
This article highlights a dilemma that we face when we turn to new tools that promise to improve on law’s imperfect governance. On the one hand, our discontent with law’s governance is both broad and deep, and much of it is rooted in the human nature of ...
Roger Brownsword
doaj   +1 more source