Results 131 to 140 of about 9,965,276 (342)

What are the Key Competencies and Skills Required for Leaders in China for the Greatest ROI? [PDF]

, 2015
Developing a leadership pipeline was the number one strategic business challenge in the American Chamber of Commerce Shanghai 2010 survey, even ahead of increasing market share and new innovations.
Kovack, Kasey S
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

What are the Key Practices that STEM & Manufacturing based Companies are Deploying to Drive Improvements in the Diversity of their Workforce? [PDF]

, 2015
Studies have shown that approximately 67% of U.S. manufacturing companies are currently facing a worker shortage. This rate is dramatically higher than that of other private firms in the U.S. (See Appendix A).
Hackett, Alison
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Search for Eccentric Binary Black Hole Mergers with Advanced LIGO and Advanced Virgo during Their First and Second Observing Runs [PDF]

, 2019
When formed through dynamical interactions, stellar-mass binary black holes (BBHs) may retain eccentric orbits (e > 0.1 at 10 Hz) detectable by ground-based gravitational-wave detectors.
Abbott, BP, Abbott, R, Abbott, TD, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, RX, Adya, VB, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, OD, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Aloy, MA, Altin, PA, Amato, A, Anand, S, Ananyeva, A, Anderson, SB, Anderson, WG, Angelova, SV, Antier, S, Appert, S, Arai, K, Araya, MC, Areeda, JS, Arnaud, N, Aronson, SM, Arun, KG, Arène, M, Ascenzi, S, Ashton, G, Aston, SM, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Avila-Alvarez, A, Babak, S, Bacon, P, Badaracco, F, Bader, MKM, Bae, S, Baird, J, Baker, PT, Baldaccini, F, Ballardin, G, Ballmer, SW, Bals, A, Banagiri, S, Barayoga, JC, Barbieri, C, Barclay, SE, Barish, BC, Barker, D, Barkett, K, Barnum, S, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, JC, Bazzan, M, Bejger, M, Belahcene, I, Bell, AS, Beniwal, D, Benjamin, MG, Bergmann, G, Bernuzzi, S, Berry, CPL, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bidler, J, Biggs, E, Bilenko, IA, Bilgili, SA, Billingsley, G, Birney, R, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bécsy, B   +99 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Exotopy: Mikhail Bakhtin and Jacques Lacan on the Outside Context of Discourse [PDF]

Slavica TerGestina, 2018
The present text treats the concept of exotopy in Bakhtin and Lacan, explicating the direction and the possible indices for comparison between post-Marxism and Psychoanalysis.
Kalinova, Maria
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Automation and Robotics Pilot Lines in the Context of Industry 5.0

Applied Sciences
Pilot lines have become a key element in modern industry. The demands for resilience, human-centricity, and sustainability in Industry 5.0, combined with technological innovations, highlight the critical role of these lines in the new industrial paradigm.
Rubén Alonso, Tomás F. Sánchez, Diego A. Alfaro, Yarens J. Cruz, Alberto Villalonga, Fernando Castaño   +5 more
doaj   +1 more source