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Human chorionic gonadotropin in cancer
Clinical Biochemistry, 2004Human chorionic gonadotropin (hCG) is mainly used for detection and monitoring of pregnancy and pregnancy-related disorders but it is also an extremely sensitive and specific marker for trophoblastic tumors of placental and germ cell origin. Thus treatment of relapsing choriocarcinomas and testicular germ cell tumors is often initiated on the basis of ...
Kristina Hotakainen +2 more
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Radioimmunoassay for human chorionic gonadotropin
American Journal of Obstetrics and Gynecology, 1968Abstract A radioimmunoassay method for HCG utilizing I 125 for iodination and a chemical procedure for separation of free and bound HCG 125 are described. This method is more sensitive and more accurate than the hemagglutination inhibition technique.
Myroslaw M. Hreshchyshyn, Yutaka Tomoda
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Immunochemistry of Human Chorionic Gonadotropin
1984In states of gestational trophoblastic disease, knowledge of the immunochemistry of human chorionic gonadotropin (hCG) is principally of value in relation to its use as a diagnostic tool and as a marker for the persistence of disease activity during chemotherapy (1, 2).
William R. Moyle +3 more
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Immunocytochemistry of human chorionic gonadotropin in human chorionic villi
American Journal of Obstetrics and Gynecology, 1987The immunocytochemical localization of human chorionic gonadotropin was investigated in chorionic villi from the seventh to twelfth week of gestation. By the light microscopic peroxidase-antiperoxidase technique, positive reactions of human chorionic gonadotropin were found exclusively in the syncytiotrophoblast.
Kunshige Hamasaki +4 more
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Studies of Human Chorionic Gonadotropin
1971Publisher Summary This chapter focuses on human chorionic gonadotropin (HCG), a glycoprotein hormone produced by the placenta that appears in significant quantities in the urine during the first trimester of pregnancy. The mean level of urinary HCG produced during the first trimester is 30,000–50,000 IU in 24 hours, equivalent to a maximum of ...
Sandra Kammerman +4 more
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Antibodies to human chorionic gonadotropin in humans
Clinica Chimica Acta, 1981Very few observations have been published about the development of antibodies against gonadotropins in the human. Human FSHand hCG-antibodies have been detected in a patient with isolated FSH-deficiency after human menopausal gonadotropin administration [l], or after human menopausal (hMG) and chorionic gonadotropin (hCG) administration in women with ...
A. Wolf, Christian Lauritzen, K. Musch
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Human chorionic gonadotropin in pregnancy diagnostics
Clinica Chimica Acta, 2011Human chorionic gonadotropin (hCG) is a 237 aminoacid glycoprotein hormone composed of two dissimilar α and β subunits noncovalently linked by charge interactions, which are both required for the biological activity of the hormone. Due to structural heterogeneity, hCG exists in biological fluids as a mixture of different isoforms, i.e., intact active ...
MONTAGNANA, Martina +4 more
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Archives of Andrology, 1988
We measured testicular human chorionic gonadotropin (hCG) receptors in 30 infertile men either before or 1, 3, 5, 7, or 14 days after a single administration of 5000 IU of hCG. For 5 days the administration of hCG significantly reduced the testicular binding of 125I-hCG compared with that of the testes before administration.
Kunio Matsumoto +8 more
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We measured testicular human chorionic gonadotropin (hCG) receptors in 30 infertile men either before or 1, 3, 5, 7, or 14 days after a single administration of 5000 IU of hCG. For 5 days the administration of hCG significantly reduced the testicular binding of 125I-hCG compared with that of the testes before administration.
Kunio Matsumoto +8 more
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Hormone Research, 1988
Changes in rat and human testicular human chorionic gonadotropin (hCG) binding sites induced by hCG were estimated in vivo and in vitro. After a single administration of hCG, the specific 125I-hCG bindings were significantly reduced for 7 and 5 days in rat and human testes, respectively.
Takao Sonoda +8 more
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Changes in rat and human testicular human chorionic gonadotropin (hCG) binding sites induced by hCG were estimated in vivo and in vitro. After a single administration of hCG, the specific 125I-hCG bindings were significantly reduced for 7 and 5 days in rat and human testes, respectively.
Takao Sonoda +8 more
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THE CYTOLOGICAL LOCALIZATION OF HUMAN CHORIONIC GONADOTROPIN
Canadian Journal of Biochemistry and Physiology, 1963The indirect fluorescent antibody technique was used to determine the cellular site of human chorionic gonadotropin (H.C.G.) in normal and toxaemic placentas, and in choriocarcinomas. In placental tissue specific fluorescence was located in the syncytial cells of the chorionic villi but not in the cytotrophoblast cells.
Arthur Leznoff, Bernard A. Davis
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