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Human chorionic gonadotropin and malignant mesothelioma
Cancer, 1979A 56-year-old male presented with ascites and gynecomastia. Laparoscopy demonstrated peritoneal tumors which were biopsied. Conventional histology and electron microscopy revealed the tumor to be a malignant mesothelioma. The ascitic fluid and tumor cell lysate, but not serum, contained hCG by specific assay, and the immunoreactive hCG had ...
Stuart Rich+5 more
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Biosynthesis of Human Chorionic Gonadotropin*
Endocrine Reviews, 1980HUMAN chorionic gonadotropin (hCG) is a glycoprotein hormone normally secreted by trophoblastic cells of the placenta during pregnancy. Trophoblastic tumors and some nontrophoblastic tumors also secrete hCG and/or its α- or β-subunit. This review emphasizes a number of aspects, some controversial, of hCG biosynthesis and secretion that have received ...
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Carboxypeptidase Digestion of Human Chorionic Gonadotropin
Endocrine Research Communications, 1977Native human chorionic gonadotropin (hCG) was resistant to carboxypeptidase digestion even in the presence of urea. Isolated alpha subunit of the hormone (hCG-alpha), though unreactive to enzyme treatment in the absence of denaturant, released up to four amino acid residues from the C-terminus on incubation with a mixture of carboxypeptidases A and B ...
V. G. Hum, H. G. Botting, K. F. Mori
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Thyrotropic Action of Human Chorionic Gonadotropin
Thyroid, 1995Hyperthyroidism or increased thyroid function has been reported in many patients with trophoblastic tumors. In these cases, greatly increased human chorionic gonadotropin (hCG) levels and suppressed TSH levels suggest that hCG has thyrotropic activity.
Jerome M. Hershman, Masayoshi Yoshimura
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Purification and Characterization of Human Chorionic Gonadotropin [PDF]
A purified preparation of human chorionic gonadotropin has been obtained by techniques of alcohol precipitation, ion exchange chromatography and gel filtration. Evidence is presented that the product is homogeneous in size and amino acid composition, but heterogeneous in electrical charge and sialic acid content. The polypeptide portion of the molecule
Robert E. Canfield+2 more
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Human chorionic gonadotropin tests
Expert Review of Molecular Diagnostics, 2009Human chorionic gonadotropin (hCG) is not a single biological molecule. There is the regular form of hCG produced by differentiated syncytotrophoblast cells (regular hCG). This hormone primarily functions to maintain the myometrial and decidual spiral arteries, or the vascular supply of the placenta during the full course of pregnancy ...
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Biochimica et Biophysica Acta (BBA) - General Subjects, 1990
In order to determine the significance of carbohydrate residues of human chorionic gonadotropin (hCG) in receptor interaction and signal transduction leading to steroidogenesis, the effect of deglycosylated hCG (DG-hCG) was studied in vitro with two different hCG-responsive purified testicular interstitial cell fractions.
Elizabeth S. Browne+3 more
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In order to determine the significance of carbohydrate residues of human chorionic gonadotropin (hCG) in receptor interaction and signal transduction leading to steroidogenesis, the effect of deglycosylated hCG (DG-hCG) was studied in vitro with two different hCG-responsive purified testicular interstitial cell fractions.
Elizabeth S. Browne+3 more
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1973
Publisher Summary This chapter discusses human chorionic gonadotropin (HCG), the placental glycoprotein hormone. This hormone, produced by the cytotrophoblast, is comparable in biological action to pituitary luteinizing hormone (LH) or interstitial cell stimulating hormone (ICSH).
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Publisher Summary This chapter discusses human chorionic gonadotropin (HCG), the placental glycoprotein hormone. This hormone, produced by the cytotrophoblast, is comparable in biological action to pituitary luteinizing hormone (LH) or interstitial cell stimulating hormone (ICSH).
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Human chorionic gonadotropin in the ectopic gestation
International Journal of Gynecology & Obstetrics, 1985AbstractThe ectopic pregnancy is a relatively common condition in the south African black patients. The beta‐specific subunit radioimmunoassay for human chorionic gonadotrophin (HCG) was utilized in procuring information in our series of 30 patients. Levels of the hormone were significantly lower when compared to normal gestation of similar duration ...
Hilton Kort+3 more
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An Improved Purification of Human Chorionic Gonadotropin
Endocrinologia Japonica, 1973A newly improved method for obtaining a highly active human chorionic gonadotropin (HCG) has been developed. A crude HCG with an activity of about 3, 000 IU per mg was applied to an Amberlite CG-50 column equilibrated with 0.01 M ammonium acetate buffer, pH 5.0. This first purification procedure yielded two separate peaks. The pooled fraction under the
Shuichi Namba+2 more
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