Results 151 to 160 of about 2,108,756 (374)

Transhumanism as an intellectual and technological paradigm of future medicine: Opportunities and threats

Russian Studies in Culture and Society
Background. Throughout its history, humanity has faced serious challenges, from the question of death to those associated with the development of artificial intelligence.
Elena A. Smirnova
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Perlindungan Hukum terhadap Profesi Kepolisian dalam Menjalankan Tugas Pokok dan Fungsi Penyelesaian Tindak Pidana di Kepolisian Daerah (Polda) Propinsi Kepulauan Bangka Belitung [PDF]

, 2016
Legal protection is very effort to shelther the human dignity and recognize of human rights in the legal field. A country has the responsibility to socialize new regulations to its society so that they will be aware of the law and also of their rights ...
Apriana, S. J. (Shinta)
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Back to Basics: Human Rights and the Suffering Imperative [PDF]

, 2008
Anniversaries provide a conventionally appropriate opportunity to take stock and, where necessary, to remind ourselves of why we hold to the commitments we do.
Fagan, A
core  

Planetary boundaries: Guiding human development on a changing planet

Science, 2015
Will Steffen, Katherine Richardson, J. Rockström, Sarah E. Cornell, Ingo Fetzer, Elena M. Bennett, R. Biggs, Stephen R. Carpenter, Wim de Vries, C. D. de Wit, Carl Folke, D. Gerten, J. Heinke, G. M. Mace, Linn M. Persson, Veerabhadran Ramanathan, B. Reyers, S. Sörlin   +17 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Between compassion and conservatism: a genealogy of British humanitarian sensibilities [PDF]

, 2010
: The chapter explores continuities in modern British humanitarianism at its birth two hundred years ago and today. Modern British humanitarianism arose out of the contradictions between humanist ideals, expanding social sympathies, and fears of radical ...
Pupavac, Vanessa
core  

Educating for Change

, 2019
The United Nations’ Sustainable Development Goals (SDGs) framework was adopted by every member state of the United Nations in 2015, and, albeit not legally binding, it is arguably one of the greatest steps of humanity to address the identified problems ...
Brooks, Ian, Kossmann, Mario, Kossmann, Virginie   +2 more
core   +1 more source