Results 151 to 160 of about 831,336 (352)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin

, 2013
В Ф Чехун, N. Yu. Lukyanova, ANATOLIY P. BURLAKA, N Bezdenezhnykh, Svitlana Shpyleva, Volodymyr Tryndyak, Frederick A. Beland, Igor P. Pogribny   +7 more
openalex   +2 more sources

Human disturbance-related contamination in First Nation food and medicinal plants determined through a comparison of multivariate frequentist and Bayesian regression analysis [PDF]

, 2023
Katie Tribe
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Appendix C. Results obtained from other classifications of bird sensitivity to human disturbances, based on Stotz et al. 1996.

, 2016
Mariana Morais Vidal, Érica Hasui, Marco A. Pizo, Jorge Yoshio Tamashiro, Wesley Rodrigues Silva, Paulo R. Guimarães   +5 more
openalex   +1 more source

Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies [PDF]

, 2023
Norsham Juliana, Liyana Azmi, Nadia Mohd Effendy, Nur Islami Mohd Fahmi Teng, Izuddin Fahmy Abu, Nur Nabilah Abu Bakar, Sahar Azmani, Noor Anisah Abu Yazit, Suhaini Kadiman, Srijit Das   +9 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

8B34 Head stability against the disturbances of support base while upright standing in humans

, 2012
Daiki SAKAMOTO, Keiko Chiba, Yoshihiro Hagihara, Tasuku Miyoshi   +3 more
openalex   +2 more sources

Polycyclic Aromatic Hydrocarbons in Fildes Peninsula, Maritime Antarctica: Effects of Human Disturbance

, 2022
Zilan Wu, Tian Lin, Hao Sun, Ruijing Li, Xing Liu, Zhigang Guo, Xindong Ma, Ziwei Yao   +7 more
openalex   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source