Results 51 to 60 of about 45,897 (233)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Magnetic Resonance Imaging and Histopathological Visualization of Human Dural Lymphatic Vessels

Bio-Protocol, 2018
In this protocol, we describe a method to visualize and map dural lymphatic vessels in-vivo using magnetic resonance imaging (MRI) and ex-vivo using histopathological techniques.
Seung-Kwon Ha, Govind Nair, Martina Absinta, Nicholas Luciano, Daniel Reich   +4 more
doaj   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

Anatomy of Soft Tissues of the Spinal Canal [PDF]

, 1999
Background and Objectives. Important issues regarding the spread of solutions in the epidural space and the anatomy of the site of action of spinal and epidural injections are unresolved.
Quinn, Hogan, Toth, Jeffrey M.
core   +1 more source

In vivo measurements with robust silicon-based multielectrode arrays with extreme shaft lengths [PDF]

, 2013
In this paper, manufacturing and in vivo testing of extreme-long Si-based neural microelectrode arrays are presented. Probes with different shaft lengths (15–70 mm) are formed by deep reactive ion etching and have been equipped with platinum electrodes ...
Baracskay, Péter, Battistig, Gábor, Fekete, Zoltán, Fiáth, Richárd, Juhász, György, Márton, Gergely, Pongrácz, Anita, Ulbert, István   +7 more
core   +1 more source

AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats [PDF]

, 2020
© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Glioblastoma is a kind of malignant tumour and originates from the central nervous system.
Bankier, Barkal, Barria, Benros, Braganhol, Campos-Pires, Chen, Cheong, Chicoine, Crossen, D'Alessandris, d'Isa, da Silva, Dalton, Del Sol-Fernandez, Ferrandon, Froklage, Gong, Graf, Graus, Guogang Ren, Hao, Hara, He, Heppner, Hilverda, Hwang, Jacob, Janelsins, Ji, Jin Gao, Junyang Li, Lang, Liang, Limin Wu, Liu, McFarland, Meicen Liu, Meng, Mineharu, Mostofa, Murata, Myung, Nagano, Nan, Nan, Noy, Oh, Ohgaki, Okada, Ostrom, Ovais, Park, Parrott, Platten, Quant, Reichel, Reid, Ren, Ren, Ren, Saalik, Shan, Sholl, Sim, Solanki, Sorensen, Sorra, Spacek, Stupp, Stupp, Tanaka, Thompson, Thorsson, Van Dyk, Vecht, Venkatesh, Walker, Walker Ii, Wan, Wang, Wang, Weitzner, Williams, Woodward, Wu, Wu, Yang, Yang, Yang, Yang, Yu, Yu Jiang, Yuen-Ki Cheong, Zhang, Zhu, Zhuo Yang, Zong, Zou   +98 more
core   +2 more sources

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

Advanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu, Xiaojing He, Yun Liu   +11 more
wiley   +1 more source

Confocal Raman Micro-Spectroscopy for Discrimination of Glycerol Diffusivity in Ex Vivo Porcine Dura Mater

Life, 2022
Dura mater (DM) is a connective tissue with dense collagen, which is a protective membrane surrounding the human brain. The optical clearing (OC) method was used to make DM more transparent, thereby allowing to increase in-depth investigation by confocal
Ali Jaafar, Maxim E. Darvin, Valery V. Tuchin, Miklós Veres   +3 more
doaj   +1 more source

Reasoning under uncertainty: the role of two informal fallacies in an emerging scientific inquiry [PDF]

, 2002
It is now commonplace in fallacy inquiry for many of the traditional informal fallacies to be viewed as reasonable or non-fallacious modes of argument.
Cummings, L
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source