Results 211 to 220 of about 1,185,976 (353)

Integrated Self‐Powered Sensors for Continuous Foot Health Monitoring via Laser‐Induced MXene‐Composited Graphene Hybrids From Lignocellulose

open access: yesAdvanced Science, EarlyView.
This study presents a high‐performance foot‐monitoring platform based on lignocellulose‐derived laser‐induced MXenecomposited graphene hybrids (LIG@MXene). The LIG@MXene exhibits markedly improved electrical conductivity, structural stability, and multifunctionality, enabling integrated energy harvesting, sensing, Joule heating, and supercapacitor ...
Peilong Zhao   +8 more
wiley   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

open access: yesAdvanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang   +9 more
wiley   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

open access: yesAdvanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen   +5 more
wiley   +1 more source

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

open access: yesAdvanced Science, EarlyView.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz   +12 more
wiley   +1 more source

Current protected areas provide limited benefits for European river biodiversity. [PDF]

open access: yesNat Commun
Sinclair JS   +26 more
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

open access: yesAdvanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv   +29 more
wiley   +1 more source

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