Results 151 to 160 of about 871,610 (299)

Human aldolase C: gene transcriptional regulation and protein functional role

, 2011
Aldolase C is the brain-specific aldolase isoenzyme. In the human brain, aldolase C messenger and protein are expressed in a stripe-like pattern in the Purkinje cells of the cerebellum, in the inferior olives and in the Goll and Burdach nuclei of the ...
Serio, Laura
core  

Finite element and mechanobiological modelling of vascular devices [PDF]

, 2011
There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel.
Zahedmanesh, Houman
core  

Accurate human genome analysis with element avidity sequencing

BMC Bioinformatics
Background New sequencing technologies provide options for the scientific community to design studies and build clinical workflows. These options expand user choice, and can enable more accurate, scalable, or affordable workflows depending on the fit ...
Andrew Carroll, Alexey Kolesnikov, Daniel E. Cook, Lucas Brambrink, Kelly N. Wiseman, Sophie M. Billings, Semyon Kruglyak, Bryan R. Lajoie, Junhua Zhao, Shawn E. Levy, Cory Y. McLean, Kishwar Shafin, Maria Nattestad, Pi-Chuan Chang   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cognitive neuroscience in forensic science: understanding and utilizing the human element. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2015
Dror IE.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Experimentally based numerical models and numerical simulation with parameter identification of human lumbar FSUs in traction

, 2004
Numerical simulation of the behaviour of human lumbar spine segments, moreover, parameter-identification of the component organs of human lumbar FSUs are presented in traction therapies, by using FEM analysis. First, a simple 2D model, than a refined 2D
Tornyos, A., Kurutzné Kovács, Márta
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Non-linear finite element analyses of the aortic heart valve

, 2004
Includes bibliographical references.Finite element models of the aortic heart valve have been successfully used in the past to gain insight into the mechanics of the valve and to aid in understanding of valve failure.
Koch, Thorsten M
core