Results 251 to 260 of about 871,610 (299)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2. [PDF]

Nat Commun
Yu L, Yan M, Scaturro KZ, Qureshi O, Lin YL, Bartelle BB, Smith CA, Hurtado DO, Cai JJ, Dawson LA, Brunauer R, Suva LJ, Han M, Dolan CP, Muneoka K.   +14 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A mdg4 retrotransposon screen for X-linked female sterile alleles and its relationship with the transcription factor OVO. [PDF]

G3 (Bethesda)
Benner L, Oliver B.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Mineralogical and Geochemical Fingerprinting of Potentially Toxic Elements (PTEs) in Asbestos and Non-Asbestos Tremolite: Implications for Human Health. [PDF]

Geohealth
Bloise A, Fuoco I, Vespasiano G, Giorno E, Pacella A, Filicetti S, La Russa MF, Pereira D, Piersante C, Apollaro C.   +9 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

In vivo activities of E1 elements in the insulin promoter. [PDF]

Commun Biol
Noguchi H, Miyagi-Shiohira C, Sadahira T, Watanabe M, Saitoh I.   +4 more
europepmc   +1 more source

Multifocal Optical-Resolution Photoacoustic Microscopy With a Masked Single-Element Transducer. [PDF]

IEEE Trans Med Imaging
Luo X, Cao R, Hu P, Luo Y, Zeng Y, Zhang Y, Cui M, Zhou Q, Ku G, Wang LV.   +9 more
europepmc   +1 more source

Human elements

, 2005
openaire   +2 more sources